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- W2081509380 abstract "Abstract Solubilization of fibrin monomers (Fm's) is usually performed with dilute acetic acid, urea or sodium bromide. These solvents can affect the biological properties of Fm's. Therefore we describe a new method to keep Fm's in solution, under milder conditions i.e. by generating them in Dcate solutions and avoiding non-physiological conditions. The in vivo behaviour of iodinated rat Fm's injected in rats and prepared by this new method was compared with that of Fm's dissolved in acetic acid, urea or sodium bromide. Fm's prepared in Dcate solutions accumulate rapidly, within 10 minutes after injection, in all organs tested, predominantly in kidney, liver and lung, probably by interaction with endothelial cells. The blood radioactivity remains nearly constant during the first 90 minutes and decreases thereafter exponentially. Fm's dissolved in sodium bromide behave similarly. However, Fm's dissolved in acetic acid or urea behave differently and do not accumulate in organs. This suggests that Fm's loose their capability to accumulate in organs and probably to interact with endothelial cells when they have been dissolved in acetic acid or urea. The slow exponential clearance phase does not differ significantly between the various Fm's and their T 1 2'S are estimated to lie between 5 and 7 hours." @default.
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- W2081509380 date "1982-04-01" @default.
- W2081509380 modified "2023-09-25" @default.
- W2081509380 title "Comparison of the in vivo clearance of des-AA and des-AABB rat fibrin monomers prepared by different methods" @default.
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- W2081509380 doi "https://doi.org/10.1016/0006-291x(82)91086-5" @default.
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