Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081523863> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2081523863 endingPage "683" @default.
- W2081523863 startingPage "681" @default.
- W2081523863 abstract "Bretylium [(o-bromobenzyl)ethyldimethylamine] is a quaternary ammonium compound used as the tosylate salt for treatment of ventricular fibrillation in humans. A sensitive assay was developed for the determination of low bretylium concentrations in plasma and urine. The internal standards were (p-bromobenzyl)ethyldimethylammonium p-toluenesulfonate and (o-methoxybenzyl)ethyldimethylammonium p-toluenesulfonate. Samples were deproteinized with acetonitrile and extracted with methylene chloride. After the evaporation of the organic phase, the residue was reacted with sodium 2,4,5-trichlorothiophenolate in methanol. This procedure yielded volatile compounds with excellent electron-capture capabilities for the GLC analysis. The assay sensitivity is 5 ng/ml. The extraction recovery of bretylium as determined by a direct radioactivity measurement was 90 and 97% for plasma and urine, respectively. The method is highly reproducible with no significant day-to-day variations. Comparisons of 60 standard plasma samples, 25 standard urine samples, and plasma samples from a dog that received [14C]bretylium showed excellent agreement between the GLC method and direct radioactivity measurement of bretylium." @default.
- W2081523863 created "2016-06-24" @default.
- W2081523863 creator A5003566702 @default.
- W2081523863 creator A5027656459 @default.
- W2081523863 creator A5066043659 @default.
- W2081523863 creator A5073599213 @default.
- W2081523863 creator A5075806875 @default.
- W2081523863 creator A5090526461 @default.
- W2081523863 date "1980-06-01" @default.
- W2081523863 modified "2023-09-25" @default.
- W2081523863 title "GLC determination of bretylium in biological fluids" @default.
- W2081523863 cites W1968886334 @default.
- W2081523863 cites W1969645365 @default.
- W2081523863 cites W2004763400 @default.
- W2081523863 cites W2058688228 @default.
- W2081523863 cites W2091190676 @default.
- W2081523863 cites W2395252202 @default.
- W2081523863 doi "https://doi.org/10.1002/jps.2600690618" @default.
- W2081523863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7205582" @default.
- W2081523863 hasPublicationYear "1980" @default.
- W2081523863 type Work @default.
- W2081523863 sameAs 2081523863 @default.
- W2081523863 citedByCount "13" @default.
- W2081523863 countsByYear W20815238632017 @default.
- W2081523863 crossrefType "journal-article" @default.
- W2081523863 hasAuthorship W2081523863A5003566702 @default.
- W2081523863 hasAuthorship W2081523863A5027656459 @default.
- W2081523863 hasAuthorship W2081523863A5066043659 @default.
- W2081523863 hasAuthorship W2081523863A5073599213 @default.
- W2081523863 hasAuthorship W2081523863A5075806875 @default.
- W2081523863 hasAuthorship W2081523863A5090526461 @default.
- W2081523863 hasConcept C158453852 @default.
- W2081523863 hasConcept C170493617 @default.
- W2081523863 hasConcept C178790620 @default.
- W2081523863 hasConcept C185592680 @default.
- W2081523863 hasConcept C2777463227 @default.
- W2081523863 hasConcept C2779117456 @default.
- W2081523863 hasConcept C2779607525 @default.
- W2081523863 hasConcept C2780026642 @default.
- W2081523863 hasConcept C43617362 @default.
- W2081523863 hasConcept C4725764 @default.
- W2081523863 hasConcept C55493867 @default.
- W2081523863 hasConceptScore W2081523863C158453852 @default.
- W2081523863 hasConceptScore W2081523863C170493617 @default.
- W2081523863 hasConceptScore W2081523863C178790620 @default.
- W2081523863 hasConceptScore W2081523863C185592680 @default.
- W2081523863 hasConceptScore W2081523863C2777463227 @default.
- W2081523863 hasConceptScore W2081523863C2779117456 @default.
- W2081523863 hasConceptScore W2081523863C2779607525 @default.
- W2081523863 hasConceptScore W2081523863C2780026642 @default.
- W2081523863 hasConceptScore W2081523863C43617362 @default.
- W2081523863 hasConceptScore W2081523863C4725764 @default.
- W2081523863 hasConceptScore W2081523863C55493867 @default.
- W2081523863 hasIssue "6" @default.
- W2081523863 hasLocation W20815238631 @default.
- W2081523863 hasLocation W20815238632 @default.
- W2081523863 hasOpenAccess W2081523863 @default.
- W2081523863 hasPrimaryLocation W20815238631 @default.
- W2081523863 hasRelatedWork W1973191583 @default.
- W2081523863 hasRelatedWork W2026973832 @default.
- W2081523863 hasRelatedWork W2028150847 @default.
- W2081523863 hasRelatedWork W2046277083 @default.
- W2081523863 hasRelatedWork W2084222250 @default.
- W2081523863 hasRelatedWork W2096475134 @default.
- W2081523863 hasRelatedWork W2150080294 @default.
- W2081523863 hasRelatedWork W2329387523 @default.
- W2081523863 hasRelatedWork W2376531500 @default.
- W2081523863 hasRelatedWork W3138239113 @default.
- W2081523863 hasVolume "69" @default.
- W2081523863 isParatext "false" @default.
- W2081523863 isRetracted "false" @default.
- W2081523863 magId "2081523863" @default.
- W2081523863 workType "article" @default.