FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081554906> ?p ?o ?g. }

• W2081554906 endingPage "527" @default.
• W2081554906 startingPage "523" @default.
• W2081554906 abstract "Resveratrol, which is found in grapes, red wine, and berries, has many beneficial health effects, such as anti-cancer, neuro-protective, anti-inflammatory, and life-prolonging effects. However, the cellular mechanisms by which resveratrol acts are relatively unknown, especially in terms of possible regulation of receptors involved in synaptic transmission. 5-Hydroxytryptamine type 3A (5-HT3A) receptor is one of several ligand-gated ion channels involved in fast synaptic transmission. In the present study, we investigated the effect of resveratrol on mouse 5-HT3A receptor channel activity. 5-HT3A receptor was expressed in Xenopus oocytes, and the current was measured using a two-electrode voltage clamp technique. Treatment of resveratrol itself had no effect on the oocytes injected with H2O as well as on the oocytes injected with 5-HT3A receptor cRNA. In the oocytes injected with 5-HT3A receptor cRNA, co- or pre-treatment of resveratrol with 5-HT potentiated 5-HT-induced inward peak current (I5-HT) with concentration-, reversible, and voltage-independent manners. The EC50 of resveratrol was 28.0±2.4 μM. The presence of resveratrol caused a leftward shift of 5-HT concentration–response curve. Protein kinase C (PKC) activator or inhibitor had no effect on resveratrol action on I5-HT. Site-directed mutations of pre-transmembrane domain 1 (pre-TM1) such as R222A, R222D, R222E, R222K, and R222T abolished or attenuated resveratrol-induced enhancement of I5-HT, indicating that resveratrol might interact with pre-TM1 of 5-HT3A receptor. These results indicate that resveratrol might regulate 5-HT3A receptor channel activity via interaction with the N-terminal domain and these results further show that resveratrol-mediated regulation of 5-HT3A receptor channel activity might be one of cellular mechanisms of resveratrol action." @default.
• W2081554906 created "2016-06-24" @default.
• W2081554906 creator A5008078794 @default.
• W2081554906 creator A5047689370 @default.
• W2081554906 creator A5055199090 @default.
• W2081554906 creator A5057682565 @default.
• W2081554906 creator A5072200429 @default.
• W2081554906 creator A5077432077 @default.
• W2081554906 creator A5084665044 @default.
• W2081554906 date "2011-01-01" @default.
• W2081554906 modified "2023-10-16" @default.
• W2081554906 title "Resveratrol Enhances 5-Hydroxytryptamine Type 3A Receptor-Mediated Ion Currents: The Role of Arginine 222 Residue in Pre-transmembrane Domain I" @default.
• W2081554906 cites W1980959448 @default.
• W2081554906 cites W1987129577 @default.
• W2081554906 cites W1996081490 @default.
• W2081554906 cites W1999154941 @default.
• W2081554906 cites W2007591527 @default.
• W2081554906 cites W2012325548 @default.
• W2081554906 cites W2021337133 @default.
• W2081554906 cites W2027315787 @default.
• W2081554906 cites W2048118540 @default.
• W2081554906 cites W2056918752 @default.
• W2081554906 cites W2066795714 @default.
• W2081554906 cites W2068852761 @default.
• W2081554906 cites W2074916731 @default.
• W2081554906 cites W2092706071 @default.
• W2081554906 cites W2093206783 @default.
• W2081554906 cites W2111092938 @default.
• W2081554906 cites W2129488948 @default.
• W2081554906 cites W2135439310 @default.
• W2081554906 cites W2199386566 @default.
• W2081554906 cites W2323170397 @default.
• W2081554906 cites W4242056496 @default.
• W2081554906 doi "https://doi.org/10.1248/bpb.34.523" @default.
• W2081554906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21467640" @default.
• W2081554906 hasPublicationYear "2011" @default.
• W2081554906 type Work @default.
• W2081554906 sameAs 2081554906 @default.
• W2081554906 citedByCount "19" @default.
• W2081554906 countsByYear W20815549062012 @default.
• W2081554906 countsByYear W20815549062013 @default.
• W2081554906 countsByYear W20815549062014 @default.
• W2081554906 countsByYear W20815549062015 @default.
• W2081554906 countsByYear W20815549062016 @default.
• W2081554906 countsByYear W20815549062017 @default.
• W2081554906 countsByYear W20815549062018 @default.
• W2081554906 countsByYear W20815549062019 @default.
• W2081554906 countsByYear W20815549062020 @default.
• W2081554906 countsByYear W20815549062021 @default.
• W2081554906 countsByYear W20815549062022 @default.
• W2081554906 countsByYear W20815549062023 @default.
• W2081554906 crossrefType "journal-article" @default.
• W2081554906 hasAuthorship W2081554906A5008078794 @default.
• W2081554906 hasAuthorship W2081554906A5047689370 @default.
• W2081554906 hasAuthorship W2081554906A5055199090 @default.
• W2081554906 hasAuthorship W2081554906A5057682565 @default.
• W2081554906 hasAuthorship W2081554906A5072200429 @default.
• W2081554906 hasAuthorship W2081554906A5077432077 @default.
• W2081554906 hasAuthorship W2081554906A5084665044 @default.
• W2081554906 hasBestOaLocation W20815549061 @default.
• W2081554906 hasConcept C104317684 @default.
• W2081554906 hasConcept C118892022 @default.
• W2081554906 hasConcept C12554922 @default.
• W2081554906 hasConcept C170493617 @default.
• W2081554906 hasConcept C185592680 @default.
• W2081554906 hasConcept C2776816829 @default.
• W2081554906 hasConcept C2779535977 @default.
• W2081554906 hasConcept C50254741 @default.
• W2081554906 hasConcept C55493867 @default.
• W2081554906 hasConcept C86803240 @default.
• W2081554906 hasConcept C98274493 @default.
• W2081554906 hasConceptScore W2081554906C104317684 @default.
• W2081554906 hasConceptScore W2081554906C118892022 @default.
• W2081554906 hasConceptScore W2081554906C12554922 @default.
• W2081554906 hasConceptScore W2081554906C170493617 @default.
• W2081554906 hasConceptScore W2081554906C185592680 @default.
• W2081554906 hasConceptScore W2081554906C2776816829 @default.
• W2081554906 hasConceptScore W2081554906C2779535977 @default.
• W2081554906 hasConceptScore W2081554906C50254741 @default.
• W2081554906 hasConceptScore W2081554906C55493867 @default.
• W2081554906 hasConceptScore W2081554906C86803240 @default.
• W2081554906 hasConceptScore W2081554906C98274493 @default.
• W2081554906 hasIssue "4" @default.
• W2081554906 hasLocation W20815549061 @default.
• W2081554906 hasLocation W20815549062 @default.
• W2081554906 hasOpenAccess W2081554906 @default.
• W2081554906 hasPrimaryLocation W20815549061 @default.
• W2081554906 hasRelatedWork W1546894681 @default.
• W2081554906 hasRelatedWork W2009199467 @default.
• W2081554906 hasRelatedWork W2019857469 @default.
• W2081554906 hasRelatedWork W2020881456 @default.
• W2081554906 hasRelatedWork W2062131043 @default.
• W2081554906 hasRelatedWork W2086360522 @default.
• W2081554906 hasRelatedWork W2398386202 @default.
• W2081554906 hasRelatedWork W2412953961 @default.
• W2081554906 hasRelatedWork W2463316005 @default.
• W2081554906 hasRelatedWork W4319931918 @default.
• W2081554906 hasVolume "34" @default.

• next