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- W2081571569 abstract "Plasma total lipids (TL), free fatty acids (FFA), triglycerides (TG) and free glycerol (FG) were measured in 11 normally grown premature neonates who received total parenteral nutrition with dextrose, amino acids and fat emulsion. Gestational ages ranged from 26 to 32 weeks, birthweights ranged from 964 to 1758g and postnatal ages ranged from 2 to 14 days. Fat emulsion was infused continuously, beginning with a daily dose of 1 g/kg on the first day and increasing by 1 g/kg each 24 hours to a daily dose of 4 g/kg. Blood samples were obtained before and 4, 8, 12 and 24 hours after each dosage change. For all lipid fractions measured the mean (±SE) concentrations increased over mean preinfusion values, differences reaching statistical significance (p<0.05) at 12 hours for TL (413±16.0 vs 327±21.3 mg/dl), at 8 hours for FFA (16.2±1.78 vs 10.6±1.19 mEq/dl), at 12 hours for FG (0.26±0.093 vs 0.16±0.030 mM/dl) and at 4 hours for TG (0.51±0.103 vs 0.30±0.031 mM/dl). The mean concentrations of all lipid fractions remained higher than their respective baselines and there was no significant change in the mean values for any particular fraction. These data suggest that the infusion of fat emulsion at 1 g/kg produces elevations of all plasma lipids but that the effects of 4 g/kg do not markedly differ from those of 1 g/kg. The tolerance of individual patients, however, varies considerably at daily dosage in excess of 2 g/kg. Studies to determine the optimal dosage of fat emulsions in small premature neonates are needed." @default.
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- W2081571569 date "1981-04-01" @default.
- W2081571569 modified "2023-09-26" @default.
- W2081571569 title "1326 PLASMA LIPIDS IN NEONATES RECEIVING FAT EMULSIONS" @default.
- W2081571569 doi "https://doi.org/10.1203/00006450-198104001-01355" @default.
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