FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081582021> ?p ?o ?g. }

• W2081582021 endingPage "339" @default.
• W2081582021 startingPage "333" @default.
• W2081582021 abstract "A simple and sensitive column-switching high-performance liquid chromatographic method for the simultaneous determination of warfarin enantiomers and their metabolites, 7-hydroxywarfarin enantiomers, in human plasma is described. Warfarin enantiomers, 7-hydroxywarfarin enantiomers, and an internal standard, diclofenac sodium, were extracted from 1 mL of a plasma sample using diethyl ether-chloroform (80:20, v/v). The extract was injected onto column I (TSK precolumn BSA-C8, 5 microm, 10 mm x 4.6 mm inside diameter) for cleanup and column II (Chiralcel OD-RH analytical column, 150 mm x 4.6 mm inside diameter) coupled with a guard column (Chiralcel OD-RH guard column, 10 mm x4.6 mm inside diameter) for separation. The mobile phase consisted of phosphate buffer-acetonitrile (84:16 v/v, pH 2.0) for clean-up and phosphate buffer-acetonitrile (45:55 v/v, pH 2.0) for separation. The peaks were monitored with an ultraviolet detector set at a wavelength of 312 nm, and total time for chromatographic separation was approximately 25 minutes. The validated concentration ranges of this method were 3 to 1000 ng/mL for (R)- and (S)-warfarin and 3 to 200 ng/mL for (R)- and (S)-7-hydroxywarfarin. Intra- and interday coefficients of variation were less than 4.4% and 4.9% for (R)-warfarin and 4.8% and 4.0% for (S)-warfarin, and 5.1% and 4.2% for (R)-7-hydroxywarfarin and 5.8% and 5.0% for (S)-7-hydroxywarfarin at the different concentrations. The limit of quantification was 3 ng/mL for both warfarin and 7-hydroxywarfarin enantiomers. This method was suitable for therapeutic drug monitoring of warfarin enantiomers and was applied in a pharmacokinetic study requiring the simultaneous determination of warfarin enantiomers and its metabolite, 7-hydroxywarfarin enantiomers, in human volunteers." @default.
• W2081582021 created "2016-06-24" @default.
• W2081582021 creator A5028660614 @default.
• W2081582021 creator A5039625500 @default.
• W2081582021 creator A5041929394 @default.
• W2081582021 creator A5064286836 @default.
• W2081582021 creator A5089208654 @default.
• W2081582021 date "2007-06-01" @default.
• W2081582021 modified "2023-09-27" @default.
• W2081582021 title "Simultaneous Determination of Warfarin Enantiomers and Its Metabolite in Human Plasma by Column-Switching High-Performance Liquid Chromatography With Chiral Separation" @default.
• W2081582021 cites W1712708601 @default.
• W2081582021 cites W1967656622 @default.
• W2081582021 cites W1968219079 @default.
• W2081582021 cites W1983687170 @default.
• W2081582021 cites W1985051341 @default.
• W2081582021 cites W1996328081 @default.
• W2081582021 cites W2010305533 @default.
• W2081582021 cites W2020510832 @default.
• W2081582021 cites W2035878568 @default.
• W2081582021 cites W2042325318 @default.
• W2081582021 cites W2043674997 @default.
• W2081582021 cites W2055771484 @default.
• W2081582021 cites W2062323684 @default.
• W2081582021 cites W2068634821 @default.
• W2081582021 cites W2088965478 @default.
• W2081582021 cites W2089523781 @default.
• W2081582021 cites W2093481286 @default.
• W2081582021 cites W2125650394 @default.
• W2081582021 cites W2152424534 @default.
• W2081582021 cites W30895175 @default.
• W2081582021 cites W4211243496 @default.
• W2081582021 doi "https://doi.org/10.1097/ftd.0b013e31805c956e" @default.
• W2081582021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17529891" @default.
• W2081582021 hasPublicationYear "2007" @default.
• W2081582021 type Work @default.
• W2081582021 sameAs 2081582021 @default.
• W2081582021 citedByCount "26" @default.
• W2081582021 countsByYear W20815820212012 @default.
• W2081582021 countsByYear W20815820212013 @default.
• W2081582021 countsByYear W20815820212014 @default.
• W2081582021 countsByYear W20815820212015 @default.
• W2081582021 countsByYear W20815820212017 @default.
• W2081582021 countsByYear W20815820212019 @default.
• W2081582021 countsByYear W20815820212021 @default.
• W2081582021 countsByYear W20815820212022 @default.
• W2081582021 crossrefType "journal-article" @default.
• W2081582021 hasAuthorship W2081582021A5028660614 @default.
• W2081582021 hasAuthorship W2081582021A5039625500 @default.
• W2081582021 hasAuthorship W2081582021A5041929394 @default.
• W2081582021 hasAuthorship W2081582021A5064286836 @default.
• W2081582021 hasAuthorship W2081582021A5089208654 @default.
• W2081582021 hasConcept C113196181 @default.
• W2081582021 hasConcept C179998833 @default.
• W2081582021 hasConcept C185592680 @default.
• W2081582021 hasConcept C2777477808 @default.
• W2081582021 hasConcept C43617362 @default.
• W2081582021 hasConcept C486523 @default.
• W2081582021 hasConcept C55493867 @default.
• W2081582021 hasConcept C71240020 @default.
• W2081582021 hasConceptScore W2081582021C113196181 @default.
• W2081582021 hasConceptScore W2081582021C179998833 @default.
• W2081582021 hasConceptScore W2081582021C185592680 @default.
• W2081582021 hasConceptScore W2081582021C2777477808 @default.
• W2081582021 hasConceptScore W2081582021C43617362 @default.
• W2081582021 hasConceptScore W2081582021C486523 @default.
• W2081582021 hasConceptScore W2081582021C55493867 @default.
• W2081582021 hasConceptScore W2081582021C71240020 @default.
• W2081582021 hasIssue "3" @default.
• W2081582021 hasLocation W20815820211 @default.
• W2081582021 hasLocation W20815820212 @default.
• W2081582021 hasOpenAccess W2081582021 @default.
• W2081582021 hasPrimaryLocation W20815820211 @default.
• W2081582021 hasRelatedWork W134413669 @default.
• W2081582021 hasRelatedWork W1970888742 @default.
• W2081582021 hasRelatedWork W1973892552 @default.
• W2081582021 hasRelatedWork W1999301148 @default.
• W2081582021 hasRelatedWork W2021792606 @default.
• W2081582021 hasRelatedWork W2055306536 @default.
• W2081582021 hasRelatedWork W2110982020 @default.
• W2081582021 hasRelatedWork W2124457351 @default.
• W2081582021 hasRelatedWork W2406364491 @default.
• W2081582021 hasRelatedWork W610504060 @default.
• W2081582021 hasVolume "29" @default.
• W2081582021 isParatext "false" @default.
• W2081582021 isRetracted "false" @default.
• W2081582021 magId "2081582021" @default.
• W2081582021 workType "article" @default.