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• W2081582314 abstract "Affinity-matured human antibodies have demonstrated efficacy as countermeasures for exposure to botulinum neurotoxin (BoNT), which is the cause of the disease botulism category A select bioterror agent. Little is known, however, about the potential role of natural (un-mutated) antibodies in the protective immune response to BoNT. Here we describe the cloning of two human IgM antibodies that bind serotype A BoNT. Both are un-mutated IgM antibodies, consistent with an origin in naive B cells. One of the antibodies is able to fully neutralize a lethal dose of serotype A BoNT in vivo. These results suggest that the natural human antibody repertoire may play a role in protection from exposure to biological toxins." @default.
• W2081582314 created "2016-06-24" @default.
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• W2081582314 date "2008-04-01" @default.
• W2081582314 modified "2023-10-10" @default.
• W2081582314 title "A Natural Human IgM Antibody that Neutralizes Botulinum Neurotoxinin vivo" @default.
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• W2081582314 doi "https://doi.org/10.1089/hyb.2007.0549" @default.
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