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- W2081597669 abstract "In our studies of structure-activity relationships, four aminonitrophenol isomers and eleven derivatives of 3-amino-4-nitrophenol and 4-amino-3-nitrophenol were tested for their ability to induce mutations in Salmonella typhimurium strains TA1535, TA100, TA1537, TA1538 and TA98. In the presence of an Aroclor-1254-induced rat-liver microsomal activation system (S9mix), 4-N-β-hydroxyethylamino-3-nitroanisole and (4-amino-3-nitro) phenoxyethanol were mutagenic in several of these strains. The compounds 3-amino-4-nitrophenol, 3-N-methylamino-4-nitrophenol, 3-N-β-hydroxyethylamino-4-nitrophenol, 3-amino-4-nitroanisole, 3-N-methylamino-4-nitroanisole, 3-N-β-hydroxyethylamino-4-nitroanisole, (3-amino-4-nitro)phenoxyethanol, (3-methylamino-4-nitro)phenoxyethanol, (3-N-β-hydroxyethylamino-4-nitro)phenoxyethanol, 4-amino-3-nitrophenol and 4-N-β-hydroxyethylamino-3-nitrophenol were inactive, both in the presence and in the absence of S9 mix. In contrast to the results with 3-amino-4-nitrophenol and 4-amino-3-nitrophenol, which were negative, the isomers 2-amino-4-nitrophenol and 2-amino-5-nitrophenol were found to be mutagenic. These results on mutagenic and non-mutagenic aminonitrophenols and their derivatives suggest that the occurrence of mutagenic activity among these compounds depends on the nature of the substituent chemical groups and their position in the molecular structure of the compounds. Aminonitriphenols: relation structure-activité Dans nos études sur les relations structure-activité, quatre isomères de l'aminonitrophénol et onze dérivés du 3-amino-4-nitrophénol et du 4-amino-3-nitrophénol, ont été testés pour la faculté qu'ils ont d'induire des mutations sur les souches de Salmonella typhimurium TA1535, TA100, TA1537, TA1538 et TA98. En présence d'un système microsomal d'activation, issue de foies de rats induits à L'Aroclor 1254 (S9 mix), le 4-N-β-hydroxyethyl-amino-3-nitroanisole et le (4-amino-3-nitro)phénoxyéthanol se sont révélés mutagènes sur plusieurs de ces souches. Les composés 3-amino-4-nitrophénol, 3-N-méthylamino-4-nitrophénol, 3-N-β-hydroxyéthylamino-4-nitrophénol, 3-amino-4-nitroanisole, 3-N-méthylamino-4-nitroanisole, 3-N-β-hydroxyéthylamino-4-nitroanisole, (3-amino-4-nitro) phénoxyéthanol, (3-méthylamino-4-nitro)phénoxyéthanol, (3-N-β-hydroxyéthylamino-4-nitro)phénoxyéthanol, 4-amino-3-nitrophénol et 4-N-β-hydroxyéthylamino-3-nitrophénol étaient inactifs, aussi bien en présence qu'en absence de S9 mix." @default.
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- W2081597669 title "Mutagenicity of aminonitrophenol compounds in Salmonella typhimurium: a study of structural-activity relationships" @default.
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- W2081597669 doi "https://doi.org/10.1111/j.1467-2494.1982.tb00297.x" @default.
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