FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081608633> ?p ?o ?g. }

• W2081608633 endingPage "160" @default.
• W2081608633 startingPage "152" @default.
• W2081608633 abstract "In the present study, we compared the use of autologous versus allogeneic fibroblasts in dermal skin substitutes in a porcine wound model. The allogeneic fibroblast populations were isolated from female and a male pig (allo‐1, ‐ 2 and ‐ 3) and the controls, autologous fibroblasts, from female graft‐recipient pigs (control). The histocompatibility of the three donor pigs with the recipient pigs was determined with a mixed lymphocyte reaction. In two pigs, full‐thickness wounds were treated with the fibroblast‐seeded dermal substitutes ( n =5 per animal) and immediately overgrafted with meshed split‐skin autografts. After 6 weeks, wound contraction was measured by planimetry and scar formation was scored. At 2, 4, and 6 weeks biopsies were taken and evaluated for the presence of inflammatory reactions, myofibroblasts, and scar formation. The mixed lymphocyte reaction of both recipient pigs showed the highest responses on peripheral blood mononuclear cells of the allo‐3 donor pig, and was low or negative for allo‐1 and allo‐2. In all “allogeneic” wounds, more inflammatory cells were observed over time along with inflammatory foci consisting of a mix of lymphocytes and granulomatous cells. After 4 weeks, myofibroblasts were absent in the control wounds, whereas in “allogeneic” wounds, myofibroblasts colocalized with inflammation foci. The final scar tissue of the “allogeneic” wounds showed granulating areas with thin, immature collagen bundles. In contrast, the control wounds showed a dermal tissue with mature collagen bundles organized randomly like in normal skin. The wounds treated with allo‐3 fibroblasts showed in both pigs a significant increase in scar formation and wound contraction when compared with control wounds. In conclusion, for optimal restoration of dermal skin function with minimal scar formation, skin substitutes containing autologous fibroblasts are preferred over skin substitutes with allogeneic fibroblasts. (WOUND REP REG 2002;10:)" @default.
• W2081608633 created "2016-06-24" @default.
• W2081608633 creator A5003762770 @default.
• W2081608633 creator A5023442229 @default.
• W2081608633 creator A5037576260 @default.
• W2081608633 creator A5049051285 @default.
• W2081608633 date "2002-05-01" @default.
• W2081608633 modified "2023-10-15" @default.
• W2081608633 title "Allogeneic fibroblasts in dermal substitutes induce inflammation and scar formation" @default.
• W2081608633 cites W1564038818 @default.
• W2081608633 cites W1964742482 @default.
• W2081608633 cites W1966268573 @default.
• W2081608633 cites W1966683771 @default.
• W2081608633 cites W1971831394 @default.
• W2081608633 cites W1975604186 @default.
• W2081608633 cites W1976422807 @default.
• W2081608633 cites W1985575307 @default.
• W2081608633 cites W1986132434 @default.
• W2081608633 cites W1986243932 @default.
• W2081608633 cites W1991519676 @default.
• W2081608633 cites W1991562873 @default.
• W2081608633 cites W1992104579 @default.
• W2081608633 cites W2004185725 @default.
• W2081608633 cites W2004458580 @default.
• W2081608633 cites W2007686646 @default.
• W2081608633 cites W2007742631 @default.
• W2081608633 cites W2009399707 @default.
• W2081608633 cites W2010880485 @default.
• W2081608633 cites W2024901911 @default.
• W2081608633 cites W2034332603 @default.
• W2081608633 cites W2036689013 @default.
• W2081608633 cites W2038685639 @default.
• W2081608633 cites W2043155505 @default.
• W2081608633 cites W2046464634 @default.
• W2081608633 cites W2055643962 @default.
• W2081608633 cites W2061134363 @default.
• W2081608633 cites W2065513176 @default.
• W2081608633 cites W2078458274 @default.
• W2081608633 cites W2088765023 @default.
• W2081608633 cites W2088864248 @default.
• W2081608633 cites W2091394453 @default.
• W2081608633 cites W2095322019 @default.
• W2081608633 cites W2131383478 @default.
• W2081608633 cites W2134150152 @default.
• W2081608633 cites W2138563048 @default.
• W2081608633 cites W2155784353 @default.
• W2081608633 cites W2161841913 @default.
• W2081608633 cites W4250269443 @default.
• W2081608633 cites W4253072663 @default.
• W2081608633 doi "https://doi.org/10.1046/j.1524-475x.2002.10901.x" @default.
• W2081608633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12100376" @default.
• W2081608633 hasPublicationYear "2002" @default.
• W2081608633 type Work @default.
• W2081608633 sameAs 2081608633 @default.
• W2081608633 citedByCount "58" @default.
• W2081608633 countsByYear W20816086332012 @default.
• W2081608633 countsByYear W20816086332013 @default.
• W2081608633 countsByYear W20816086332014 @default.
• W2081608633 countsByYear W20816086332015 @default.
• W2081608633 countsByYear W20816086332016 @default.
• W2081608633 countsByYear W20816086332017 @default.
• W2081608633 countsByYear W20816086332018 @default.
• W2081608633 countsByYear W20816086332020 @default.
• W2081608633 countsByYear W20816086332021 @default.
• W2081608633 countsByYear W20816086332022 @default.
• W2081608633 crossrefType "journal-article" @default.
• W2081608633 hasAuthorship W2081608633A5003762770 @default.
• W2081608633 hasAuthorship W2081608633A5023442229 @default.
• W2081608633 hasAuthorship W2081608633A5037576260 @default.
• W2081608633 hasAuthorship W2081608633A5049051285 @default.
• W2081608633 hasConcept C137061746 @default.
• W2081608633 hasConcept C142724271 @default.
• W2081608633 hasConcept C185592680 @default.
• W2081608633 hasConcept C202751555 @default.
• W2081608633 hasConcept C203014093 @default.
• W2081608633 hasConcept C207865475 @default.
• W2081608633 hasConcept C2776090121 @default.
• W2081608633 hasConcept C2776914184 @default.
• W2081608633 hasConcept C2777300124 @default.
• W2081608633 hasConcept C2777624698 @default.
• W2081608633 hasConcept C2778740727 @default.
• W2081608633 hasConcept C2780269544 @default.
• W2081608633 hasConcept C2780381497 @default.
• W2081608633 hasConcept C2780559512 @default.
• W2081608633 hasConcept C55493867 @default.
• W2081608633 hasConcept C57742111 @default.
• W2081608633 hasConcept C71924100 @default.
• W2081608633 hasConcept C8891405 @default.
• W2081608633 hasConceptScore W2081608633C137061746 @default.
• W2081608633 hasConceptScore W2081608633C142724271 @default.
• W2081608633 hasConceptScore W2081608633C185592680 @default.
• W2081608633 hasConceptScore W2081608633C202751555 @default.
• W2081608633 hasConceptScore W2081608633C203014093 @default.
• W2081608633 hasConceptScore W2081608633C207865475 @default.
• W2081608633 hasConceptScore W2081608633C2776090121 @default.
• W2081608633 hasConceptScore W2081608633C2776914184 @default.
• W2081608633 hasConceptScore W2081608633C2777300124 @default.
• W2081608633 hasConceptScore W2081608633C2777624698 @default.

• next