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• W2081631020 abstract "This double-blinded, placebo-controlled clinical trial tested the safety and efficacy of a topical secretory IgA antibody manufactured in tobacco plants (plantibody) in preventing recolonization of mutans streptococci (MS) in human plaque as measured by whole stimulated saliva samples.Following a 9-day antimicrobial treatment with chlorhexidine (CHX), 56 eligible adults (enrollment salivary MS > or = 10(4) CFU/ml; no current caries) were randomized equally to a group receiving 0, 2, 4, or 6 topical applications of plantibody followed by 6, 4, 2, or 0 applications of placebo, respectively, over a 3-week period.Among the 54 subjects who completed the trial, the CHX regimen eliminated salivary MS in 69%. After 6 months, there were no significant differences in MS levels by number of applications, relative to placebo (p > 0.43). No adverse effects were observed.Plantibody is safe but not effective at the frequency, concentration, and number of applications used in this study." @default.
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• W2081631020 date "2005-01-01" @default.
• W2081631020 modified "2023-09-24" @default.
• W2081631020 title "Clinical Trial of a Plant-Derived Antibody on Recolonization of Mutans Streptococci" @default.
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• W2081631020 doi "https://doi.org/10.1159/000084805" @default.
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