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- W2081636275 abstract "It is estimated that over 10% of women have pigmented lesions of the vulva including vulvar melanosis, lentigines, melanocytic nevi and rarely melanoma. A small number of nevi in children and young women present a diagnostic and therapeutic dilemma due to their histopathologic similarities to melanoma. These nevi typically have large, irregularly shaped and irregularly positioned nests that may be confluent along the dermo-epidermal junction. There may be clefting between the junctional melanocytic nests and the underlying dermis and limited “pagetoid” scatter of melanocytes. Melanocytes within nests may be separated from each other giving a “dyscohesive” appearance. The junctional and most superficial dermal melanocytes may be large, with abundant pale cytoplasm. The pathology may be altered further by coexistent lichen sclerosus. A case of a large circumferential vulvar nevus, complicated by lichen sclerosus, in a 12-year-old girl illustrates the characteristics of these histologically anomalous vulvar nevi. Vulvar melanoma is a deadly disease that often presents in an advanced state in elderly women. Its occurrence in children is distinctly rare. Correct diagnosis of histologically unusual vulvar nevi, especially in young women and children, is important to avoid unnecessary and morbid surgery." @default.
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- W2081636275 date "2005-01-01" @default.
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- W2081636275 title "A Histologically Anomalous Nevus of the Vulva in a 12-Year-Old Girl" @default.
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- W2081636275 doi "https://doi.org/10.1097/01.pcr.0000154109.52847.16" @default.
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