FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081667222> ?p ?o ?g. }

• W2081667222 endingPage "479" @default.
• W2081667222 startingPage "469" @default.
• W2081667222 abstract "Activated protein C functions directly as an anticoagulant and indirectly as a profibrinolytic enzyme. To determine whether the fibrin deposition previously observed in PC(-/-) murine embryos and neonates was mediated through the FXI pathway, PC(+/-)/FXI(-/-) mice were generated and crossbred to produce double-deficient progeny (PC(-/-)/FXI(-/-)). PC(-/-)/FXI(-/-) mice survived the early lethality observed in the PC(-/-)/FXI(+/+) neonates, with the oldest PC(-/-)/FXI(-/-) animal living to 3 months of age. However, the majority of these animals was sedentary and significantly growth-retarded. On sacrifice or natural death, all of these PC(-/-)/FXI(-/-) mice demonstrated massive systemic fibrin deposition with concomitant hemorrhage and fibrosis, as confirmed through histological analyses. Several of these animals also presented with enlarged lymph nodes and extensive lymphatic fluid in the thoracic cavity. Thus, although a number of the PC(-/-)/FXI(-/-) mice survived the lethal perinatal coagulopathy seen in the PC(-/-) neonates, they nonetheless succumbed to overwhelming thrombotic disease in later life. This combined deficiency state provided the first clear indication that the course of a severe thrombotic disorder could be manipulated by blocking the intrinsic pathway and provided the first opportunity to study a total protein C deficiency in an adult animal." @default.
• W2081667222 created "2016-06-24" @default.
• W2081667222 creator A5007291318 @default.
• W2081667222 creator A5011142558 @default.
• W2081667222 creator A5012332375 @default.
• W2081667222 creator A5021496734 @default.
• W2081667222 creator A5039820438 @default.
• W2081667222 creator A5040996304 @default.
• W2081667222 creator A5050593261 @default.
• W2081667222 creator A5050983927 @default.
• W2081667222 creator A5068611545 @default.
• W2081667222 creator A5074871163 @default.
• W2081667222 creator A5075780525 @default.
• W2081667222 date "2001-02-01" @default.
• W2081667222 modified "2023-09-28" @default.
• W2081667222 title "The Characterization of Mice with a Targeted Combined Deficiency of Protein C and Factor XI" @default.
• W2081667222 cites W132642117 @default.
• W2081667222 cites W1512983489 @default.
• W2081667222 cites W1525413164 @default.
• W2081667222 cites W1537023075 @default.
• W2081667222 cites W1549602366 @default.
• W2081667222 cites W157493412 @default.
• W2081667222 cites W172709144 @default.
• W2081667222 cites W1814990234 @default.
• W2081667222 cites W1960915004 @default.
• W2081667222 cites W1974486772 @default.
• W2081667222 cites W1979708961 @default.
• W2081667222 cites W1980551454 @default.
• W2081667222 cites W1988112361 @default.
• W2081667222 cites W1991316028 @default.
• W2081667222 cites W1991563262 @default.
• W2081667222 cites W2016918804 @default.
• W2081667222 cites W2027681977 @default.
• W2081667222 cites W2029413075 @default.
• W2081667222 cites W2033408570 @default.
• W2081667222 cites W2038058775 @default.
• W2081667222 cites W2066822578 @default.
• W2081667222 cites W2103233384 @default.
• W2081667222 cites W2112348962 @default.
• W2081667222 cites W2160388336 @default.
• W2081667222 cites W2170928419 @default.
• W2081667222 cites W2173025320 @default.
• W2081667222 cites W22019582 @default.
• W2081667222 cites W2402274498 @default.
• W2081667222 cites W3116136139 @default.
• W2081667222 cites W314977035 @default.
• W2081667222 doi "https://doi.org/10.1016/s0002-9440(10)63989-2" @default.
• W2081667222 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1850297" @default.
• W2081667222 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11159184" @default.
• W2081667222 hasPublicationYear "2001" @default.
• W2081667222 type Work @default.
• W2081667222 sameAs 2081667222 @default.
• W2081667222 citedByCount "35" @default.
• W2081667222 countsByYear W20816672222012 @default.
• W2081667222 countsByYear W20816672222015 @default.
• W2081667222 countsByYear W20816672222016 @default.
• W2081667222 countsByYear W20816672222017 @default.
• W2081667222 countsByYear W20816672222019 @default.
• W2081667222 countsByYear W20816672222021 @default.
• W2081667222 countsByYear W20816672222023 @default.
• W2081667222 crossrefType "journal-article" @default.
• W2081667222 hasAuthorship W2081667222A5007291318 @default.
• W2081667222 hasAuthorship W2081667222A5011142558 @default.
• W2081667222 hasAuthorship W2081667222A5012332375 @default.
• W2081667222 hasAuthorship W2081667222A5021496734 @default.
• W2081667222 hasAuthorship W2081667222A5039820438 @default.
• W2081667222 hasAuthorship W2081667222A5040996304 @default.
• W2081667222 hasAuthorship W2081667222A5050593261 @default.
• W2081667222 hasAuthorship W2081667222A5050983927 @default.
• W2081667222 hasAuthorship W2081667222A5068611545 @default.
• W2081667222 hasAuthorship W2081667222A5074871163 @default.
• W2081667222 hasAuthorship W2081667222A5075780525 @default.
• W2081667222 hasBestOaLocation W20816672221 @default.
• W2081667222 hasConcept C126322002 @default.
• W2081667222 hasConcept C134018914 @default.
• W2081667222 hasConcept C142724271 @default.
• W2081667222 hasConcept C203014093 @default.
• W2081667222 hasConcept C2779936836 @default.
• W2081667222 hasConcept C2781221834 @default.
• W2081667222 hasConcept C54173615 @default.
• W2081667222 hasConcept C71924100 @default.
• W2081667222 hasConcept C86803240 @default.
• W2081667222 hasConceptScore W2081667222C126322002 @default.
• W2081667222 hasConceptScore W2081667222C134018914 @default.
• W2081667222 hasConceptScore W2081667222C142724271 @default.
• W2081667222 hasConceptScore W2081667222C203014093 @default.
• W2081667222 hasConceptScore W2081667222C2779936836 @default.
• W2081667222 hasConceptScore W2081667222C2781221834 @default.
• W2081667222 hasConceptScore W2081667222C54173615 @default.
• W2081667222 hasConceptScore W2081667222C71924100 @default.
• W2081667222 hasConceptScore W2081667222C86803240 @default.
• W2081667222 hasIssue "2" @default.
• W2081667222 hasLocation W20816672221 @default.
• W2081667222 hasLocation W20816672222 @default.
• W2081667222 hasLocation W20816672223 @default.
• W2081667222 hasLocation W20816672224 @default.
• W2081667222 hasOpenAccess W2081667222 @default.
• W2081667222 hasPrimaryLocation W20816672221 @default.

• next