FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081672495> ?p ?o ?g. }

• W2081672495 endingPage "697" @default.
• W2081672495 startingPage "690" @default.
• W2081672495 abstract "In mammals, X-chromosome inactivation (XCI) ensures equal expression of X-linked genes in XX and XY individuals by transcriptionally silencing one X-chromosome in female cells. In this review, we discuss an imprinted form of X-inactivation in which the paternal X (Xp) is preferentially silenced. Believed to be the ancestral mechanism of dosage compensation in mammals, imprinted X-inactivation can still be observed in modern-day marsupials and in the extraembryonic tissues of some eutherians such as the mouse. Recent experiments have addressed the nature of the gametic imprint and focused on the regulatory interaction between the noncoding RNA gene, Xist, and its antisense partner, Tsix. Our review of the literature has inspired an unconventional view of imprinted XCI in mice. First, the evidence strongly argues that imprinted XCI is inabsolute, so that a stochastic number of extraembryonic cells escape imprinting. Second, contrary to conventional thinking, we would like to consider the possibility that the paternal X might actually be transmitted to the zygote as a pre-inactivated chromosome. In this model, the gamete initiates and establishes imprinted XCI, while the zygote maintains the pre-established pattern of gametic inactivation. Finally, we hypothesize that the inabsolute nature of imprinting is caused by imperfect zygotic maintenance. We propose that the mouse represents a transitional stage in the evolution of random XCI from an absolutely imprinted mechanism." @default.
• W2081672495 created "2016-06-24" @default.
• W2081672495 creator A5007941136 @default.
• W2081672495 creator A5052374612 @default.
• W2081672495 date "2001-12-01" @default.
• W2081672495 modified "2023-09-25" @default.
• W2081672495 title "Imprinted X inactivation in eutherians: a model of gametic execution and zygotic relaxation" @default.
• W2081672495 cites W1535914077 @default.
• W2081672495 cites W1841858209 @default.
• W2081672495 cites W1882649803 @default.
• W2081672495 cites W1968767056 @default.
• W2081672495 cites W1973445288 @default.
• W2081672495 cites W1974671951 @default.
• W2081672495 cites W1984218466 @default.
• W2081672495 cites W1994670375 @default.
• W2081672495 cites W1995159539 @default.
• W2081672495 cites W2008930108 @default.
• W2081672495 cites W2012276401 @default.
• W2081672495 cites W2019531974 @default.
• W2081672495 cites W2021122622 @default.
• W2081672495 cites W2028907427 @default.
• W2081672495 cites W2029146706 @default.
• W2081672495 cites W2032737065 @default.
• W2081672495 cites W2033344369 @default.
• W2081672495 cites W2043721534 @default.
• W2081672495 cites W2047333953 @default.
• W2081672495 cites W2052764609 @default.
• W2081672495 cites W2053187427 @default.
• W2081672495 cites W2055841741 @default.
• W2081672495 cites W2056156549 @default.
• W2081672495 cites W2058342356 @default.
• W2081672495 cites W2060199527 @default.
• W2081672495 cites W2062313490 @default.
• W2081672495 cites W2068225054 @default.
• W2081672495 cites W2074199894 @default.
• W2081672495 cites W2077134893 @default.
• W2081672495 cites W2078174011 @default.
• W2081672495 cites W2079597045 @default.
• W2081672495 cites W2082968298 @default.
• W2081672495 cites W2083383771 @default.
• W2081672495 cites W2095040506 @default.
• W2081672495 cites W2107011634 @default.
• W2081672495 cites W2112535875 @default.
• W2081672495 cites W2115824539 @default.
• W2081672495 cites W2118442396 @default.
• W2081672495 cites W2128016249 @default.
• W2081672495 cites W2129578444 @default.
• W2081672495 cites W2130089202 @default.
• W2081672495 cites W2130605122 @default.
• W2081672495 cites W2135755375 @default.
• W2081672495 cites W2137081741 @default.
• W2081672495 cites W2137808356 @default.
• W2081672495 cites W2144746330 @default.
• W2081672495 cites W2145178907 @default.
• W2081672495 cites W2145666597 @default.
• W2081672495 cites W2152668402 @default.
• W2081672495 cites W2165934356 @default.
• W2081672495 cites W2167110400 @default.
• W2081672495 cites W2402293745 @default.
• W2081672495 cites W2522740 @default.
• W2081672495 cites W4238656497 @default.
• W2081672495 doi "https://doi.org/10.1016/s0955-0674(00)00272-6" @default.
• W2081672495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11698184" @default.
• W2081672495 hasPublicationYear "2001" @default.
• W2081672495 type Work @default.
• W2081672495 sameAs 2081672495 @default.
• W2081672495 citedByCount "80" @default.
• W2081672495 countsByYear W20816724952012 @default.
• W2081672495 countsByYear W20816724952013 @default.
• W2081672495 countsByYear W20816724952014 @default.
• W2081672495 countsByYear W20816724952015 @default.
• W2081672495 countsByYear W20816724952016 @default.
• W2081672495 countsByYear W20816724952017 @default.
• W2081672495 countsByYear W20816724952018 @default.
• W2081672495 countsByYear W20816724952019 @default.
• W2081672495 countsByYear W20816724952020 @default.
• W2081672495 countsByYear W20816724952021 @default.
• W2081672495 countsByYear W20816724952022 @default.
• W2081672495 countsByYear W20816724952023 @default.
• W2081672495 crossrefType "journal-article" @default.
• W2081672495 hasAuthorship W2081672495A5007941136 @default.
• W2081672495 hasAuthorship W2081672495A5052374612 @default.
• W2081672495 hasConcept C104317684 @default.
• W2081672495 hasConcept C110411900 @default.
• W2081672495 hasConcept C119056186 @default.
• W2081672495 hasConcept C150194340 @default.
• W2081672495 hasConcept C190727270 @default.
• W2081672495 hasConcept C201492766 @default.
• W2081672495 hasConcept C28748434 @default.
• W2081672495 hasConcept C35158069 @default.
• W2081672495 hasConcept C4323932 @default.
• W2081672495 hasConcept C54355233 @default.
• W2081672495 hasConcept C86803240 @default.
• W2081672495 hasConcept C87073359 @default.
• W2081672495 hasConcept C92509807 @default.
• W2081672495 hasConcept C94715292 @default.
• W2081672495 hasConcept C95444343 @default.
• W2081672495 hasConceptScore W2081672495C104317684 @default.

• next