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- W2081679244 abstract "The cannabinoid receptor 1 (CB<sub>1</sub>R) is required for body weight homeostasis and normal gastrointestinal motility. However, the specific cell types expressing CB<sub>1</sub>R that regulate these physiological functions are unknown. CB<sub>1</sub>R is widely expressed, including in neurons of the parasympathetic branches of the autonomic nervous system. The vagus nerve has been implicated in the regulation of several aspects of metabolism and energy balance (e.g., food intake and glucose balance), and gastrointestinal functions including motility. To directly test the relevance of CB<sub>1</sub>R in neurons of the vagus nerve on metabolic homeostasis and gastrointestinal motility, we generated and characterized mice lacking CB<sub>1</sub>R in afferent and efferent branches of the vagus nerve (<i>Cnr1<sup>flox/flox</sup>; Phox2b–Cre</i> mice). On a chow or on a high-fat diet, <i>Cnr1<sup>flox/flox</sup>; Phox2b–Cre</i> mice have similar body weight, food intake, energy expenditure, and glycemia compared with <i>Cnr1<sup>flox/flox</sup></i> control mice. Also, fasting-induced hyperphagia and after acute or chronic pharmacological treatment with SR141716 [<i>N</i>-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-3-pyrazole carboxamide] (CB<sub>1</sub>R inverse agonist) paradigms, mutants display normal body weight and food intake. Interestingly, <i>Cnr1<sup>flox/flox</sup>; Phox2b–Cre</i> mice have increased gastrointestinal motility compared with controls. These results unveil CB<sub>1</sub>R in the vagus nerve as a key component underlying normal gastrointestinal motility." @default.
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- W2081679244 date "2012-07-25" @default.
- W2081679244 modified "2023-09-30" @default.
- W2081679244 title "Cannabinoid Receptor 1 in the Vagus Nerve Is Dispensable for Body Weight Homeostasis But Required for Normal Gastrointestinal Motility" @default.
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- W2081679244 doi "https://doi.org/10.1523/jneurosci.4507-11.2012" @default.
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