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- W2081680282 abstract "The in vitro biological activities of several rabies virus-neutralizing monoclonal antibodies (mAbs) were compared with their ability to prevent a lethal rabies virus encephalomyelitis. The protective activity of a particular mAb in vivo did not correlate with its virus-neutralizing activity in vitro; rather it was related to the mAb's ability to inhibit virus spread from cell to cell and to restrict rabies virus RNA transcription. Since treatment of rabies virus-infected cells with virus-neutralizing mAbs results in an endocytosis of the antibody, we hypothesize that an antibody may exert its inhibitory activity even after uptake by the cell. Post-exposure treatment of rats with a mAb that inhibited both virus spread and virus RNA transcription in vitro resulted in viral clearance from the central nervous system and protected the animals against a lethal rabies virus infection." @default.
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- W2081680282 date "1992-08-01" @default.
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- W2081680282 title "Delineation of putative mechanisms involved in antibody-mediated clearance of rabies virus from the central nervous system." @default.
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- W2081680282 doi "https://doi.org/10.1073/pnas.89.15.7252" @default.
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