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- W2081691036 abstract "Abstract In this work, the use of MRI to stage gastric neoplasia in a mouse model of spontaneous gastric cancer is demonstrated. The methodology involves 1) the use of deuterated water ( 2 H 2 O) to distend the stomach, and to provide negative contrast between the stomach and the lumen without inducing susceptibility‐based field shifts; 2) GlucaGen® to minimize motion artifacts that arise from peristalsis; and 3) Gd‐DTPA to enhance contrast between the dysplasia/tumor and the normal wall. Initial images are presented from a Tff1 −/− homozygous knock‐out model of gastric cancer and a heterozygous C57BL6/J control mouse. There are clear differences between the two types of animals in the MR appearance of the stomach. The distended stomach of the control mouse has a smooth perimeter and a thin wall, and an absence of nodules. The stomach of the Tff1 −/− mouse demonstrates a thickened wall; a jagged, irregular surface; and protruding nodules that are bright after injection of Gd‐DTPA. Magn Reson Med 49:1033–1036, 2003. © 2003 Wiley‐Liss, Inc." @default.
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- W2081691036 date "2003-05-16" @default.
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- W2081691036 title "Magnetic resonance imaging of gastric cancer inTff1 knock-out mice" @default.
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- W2081691036 doi "https://doi.org/10.1002/mrm.10458" @default.
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