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• W2081692893 abstract "The objective of the present work was to develop a delayed-onset controlled-release colon-targeted system of theophylline, and to achieve the chronotherapy of nocturnal asthma. The formulation consisted of a core tablet containing hydroxypropyl methylcellulose used for achieving controlled release of drug, and a Eudragit® S100:ethyl cellulose (EC) coating capable of delaying the drug release. The system was optimized using a 32 full factorial design, wherein two factors [ratio of Eudragit® S100:EC and the coating level (% w/w)] were evaluated for lag time, t50 and t80. The optimum formulation consisted of Eudragit® S100:EC in a 60:40 ratio and a coating level of 7.5% (w/w). Results showed that the tablets prepared according to the optimized values released no drug in the upper part of gastrointestinal tract; drug release was initiated at pH 6.4 (colon) after a lag time of 5 h. In vivo evaluation (pharmacokinetic studies and roentgenography) in rabbits revealed that the tablet remained intact until it reaches the colon and the drug release was initiated after a lag time of 5 h. Thus, it can be concluded that the developed system exhibited a promising colonic targeting and hence may be used for chronotherapy of nocturnal asthma." @default.
• W2081692893 created "2016-06-24" @default.
• W2081692893 creator A5036123559 @default.
• W2081692893 creator A5055201318 @default.
• W2081692893 date "2011-05-01" @default.
• W2081692893 modified "2023-10-01" @default.
• W2081692893 title "Design and Optimization of Colon-Targeted System of Theophylline for Chronotherapy of Nocturnal Asthma" @default.
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• W2081692893 doi "https://doi.org/10.1002/jps.22406" @default.
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