FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081707092> ?p ?o ?g. }

• W2081707092 endingPage "146" @default.
• W2081707092 startingPage "141" @default.
• W2081707092 abstract "A pilot exploratory study was undertaken to collect preliminary information relating to safety and overall outcome in using intravenous fluconazole (FLUC) for managing antibiotic resistant neutropenic fever (ARNF), with the objective of assessing feasibility of performing a larger prospective controlled study. Patients who were neutropenic from treatment for leukaemia or bone marrow transplantation, received either fluconazole (FLUC) or amphotericin B (AB). Eight of 16 patients (50%) on FLUC and 21 of 25 patients (84%) on AB defervesced; the mean time to defervescence was 11.0 +/- 10.0 days for FLUC compared to 7.7 +/- 6.3 days for AB, and a similar proportion in each treatment group defervesced within 5 days (50% vs. 52%), respectively. Six of 16 patients (37.5%) on FLUC and three of 25 patients (12%) on AB developed overt invasive fungal disease, including pulmonary aspergillosis (FLUC 4 cases, AB 2 cases) and invasive candidiasis (FLUC 2 cases, AB 0 cases). The mean time to these events was 19.5 +/- 13.4 (FLUC) and 9.0 +/- 3.6 (AB) days. The fungal related mortality rates were higher in the FLUC group: five of 16 patients (31%) vs. two of 25 patients (18%) died respectively; the time to fungal death was 43.2 +/- 18.2 (FLUC) and 25.0 +/- 18.4 (AB) days. This tendency towards a more favourable outcome in patients on AB may have been due to absence of prior fluconazole prophylaxis in patients subsequently receiving IV FLUC. Analysis of a small subgroup of patients who had all received prior prophylaxis with clotrimazole only, indicated that a greater number of patients subsequently receiving IV FLUC died from fungal disease (5/16 vs.0/6, P = 0.09).(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
• W2081707092 created "2016-06-24" @default.
• W2081707092 creator A5005246553 @default.
• W2081707092 creator A5009565651 @default.
• W2081707092 creator A5039035175 @default.
• W2081707092 creator A5067236196 @default.
• W2081707092 creator A5072363530 @default.
• W2081707092 creator A5072701608 @default.
• W2081707092 creator A5075336024 @default.
• W2081707092 creator A5088248868 @default.
• W2081707092 date "1995-03-01" @default.
• W2081707092 modified "2023-10-16" @default.
• W2081707092 title "Systemic amphotericin B versus fluconazole in the management of antibiotic resistant neutropenic fever — preliminary observations from a pilot, exploratory study" @default.
• W2081707092 cites W1040403002 @default.
• W2081707092 cites W1971920484 @default.
• W2081707092 cites W1973786578 @default.
• W2081707092 cites W2008554701 @default.
• W2081707092 cites W2044521096 @default.
• W2081707092 cites W2054034736 @default.
• W2081707092 cites W2107963912 @default.
• W2081707092 cites W2114208000 @default.
• W2081707092 cites W2167867126 @default.
• W2081707092 cites W2317836667 @default.
• W2081707092 cites W2320377369 @default.
• W2081707092 cites W2324671927 @default.
• W2081707092 cites W2327998360 @default.
• W2081707092 cites W2341266869 @default.
• W2081707092 cites W1966496737 @default.
• W2081707092 doi "https://doi.org/10.1016/s0163-4453(95)80009-3" @default.
• W2081707092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7636280" @default.
• W2081707092 hasPublicationYear "1995" @default.
• W2081707092 type Work @default.
• W2081707092 sameAs 2081707092 @default.
• W2081707092 citedByCount "20" @default.
• W2081707092 countsByYear W20817070922014 @default.
• W2081707092 countsByYear W20817070922016 @default.
• W2081707092 countsByYear W20817070922017 @default.
• W2081707092 crossrefType "journal-article" @default.
• W2081707092 hasAuthorship W2081707092A5005246553 @default.
• W2081707092 hasAuthorship W2081707092A5009565651 @default.
• W2081707092 hasAuthorship W2081707092A5039035175 @default.
• W2081707092 hasAuthorship W2081707092A5067236196 @default.
• W2081707092 hasAuthorship W2081707092A5072363530 @default.
• W2081707092 hasAuthorship W2081707092A5072701608 @default.
• W2081707092 hasAuthorship W2081707092A5075336024 @default.
• W2081707092 hasAuthorship W2081707092A5088248868 @default.
• W2081707092 hasConcept C126322002 @default.
• W2081707092 hasConcept C141071460 @default.
• W2081707092 hasConcept C16005928 @default.
• W2081707092 hasConcept C2776694085 @default.
• W2081707092 hasConcept C2777063308 @default.
• W2081707092 hasConcept C2779548794 @default.
• W2081707092 hasConcept C2779629538 @default.
• W2081707092 hasConcept C2780651595 @default.
• W2081707092 hasConcept C71924100 @default.
• W2081707092 hasConcept C90924648 @default.
• W2081707092 hasConceptScore W2081707092C126322002 @default.
• W2081707092 hasConceptScore W2081707092C141071460 @default.
• W2081707092 hasConceptScore W2081707092C16005928 @default.
• W2081707092 hasConceptScore W2081707092C2776694085 @default.
• W2081707092 hasConceptScore W2081707092C2777063308 @default.
• W2081707092 hasConceptScore W2081707092C2779548794 @default.
• W2081707092 hasConceptScore W2081707092C2779629538 @default.
• W2081707092 hasConceptScore W2081707092C2780651595 @default.
• W2081707092 hasConceptScore W2081707092C71924100 @default.
• W2081707092 hasConceptScore W2081707092C90924648 @default.
• W2081707092 hasIssue "2" @default.
• W2081707092 hasLocation W20817070921 @default.
• W2081707092 hasLocation W20817070922 @default.
• W2081707092 hasOpenAccess W2081707092 @default.
• W2081707092 hasPrimaryLocation W20817070921 @default.
• W2081707092 hasRelatedWork W1549514494 @default.
• W2081707092 hasRelatedWork W1972107684 @default.
• W2081707092 hasRelatedWork W2006530253 @default.
• W2081707092 hasRelatedWork W2063629503 @default.
• W2081707092 hasRelatedWork W2135619146 @default.
• W2081707092 hasRelatedWork W2163113890 @default.
• W2081707092 hasRelatedWork W2340388705 @default.
• W2081707092 hasRelatedWork W3036104523 @default.
• W2081707092 hasRelatedWork W4238063024 @default.
• W2081707092 hasRelatedWork W4251110507 @default.
• W2081707092 hasVolume "30" @default.
• W2081707092 isParatext "false" @default.
• W2081707092 isRetracted "false" @default.
• W2081707092 magId "2081707092" @default.
• W2081707092 workType "article" @default.