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• W2081710478 abstract "Cardiovascular diseases, formerly only attributed to the alterations of the stromal component, are now recognized as immune-based pathologies. Plasmacytoid Dendritic Cells (pDCs) are important immune orchestrators in heart and vessels. They highly produce IFN type I that promote the polarization of T cells towards a Th1 phenotype; however, pDCs can also participate to suppressive networks via the recruitment of T regulatory cells that downmodulate proinflammatory responses. pDCs populate the vessel wall layers during pathological conditions, such as atherosclerosis. It is thus clear that a better identification of pDCs activity in cardiovascular diseases can not only elucidate pathological mechanisms but also lead to new therapeutic approaches." @default.
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• W2081710478 date "2010-01-01" @default.
• W2081710478 modified "2023-09-23" @default.
• W2081710478 title "Plasmacytoid Dendritic Cells: From Heart to Vessels" @default.
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• W2081710478 doi "https://doi.org/10.1155/2010/430318" @default.
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