Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081713292> ?p ?o ?g. }
- W2081713292 endingPage "148" @default.
- W2081713292 startingPage "137" @default.
- W2081713292 abstract "Leptin, a multifunctional hormone, is present in mammalian oocytes and follicular fluids and cumulus cells. While leptin modulates oocyte maturation in vitro which seems to result in enhancement of embryo development, it is unclear whether leptin treatment of oocytes affects cytoplasmic maturation and fertilization processes. In order to gain a better understanding of the role of leptin during oocyte maturation, we examined microtubule and microfilament assembly following oocyte maturation and blastocyst formation, mitogen-activated protein kinase (MAPK) activity, and pronuclear formation following parthenogenetic stimuli or intracytoplasmic sperm injection (ICSI) in leptin-treated oocytes. Addition of 10 or 100 ng/ml leptin during oocyte maturation did not increase the proportion of metaphase II oocytes, but enhanced development to blastocyst stage by day 7 (P < 0.01) after parthenogenetic activation (PA), accompanied by increased cell number. However there was no effect on the number of apoptotic cells in blastocysts. Following maturation in the presence of leptin, there were more oocytes with normal spindle formation. MAPK activity decreased more rapidly, and pronuclear formation was accelerated after parthenogenetic activation or ICSI of leptin-treated oocytes. These results suggested that exogeneous leptin enhanced spindle assembly and accelerated pronuclear formation following fertilization, possibly via the MAPK pathway." @default.
- W2081713292 created "2016-06-24" @default.
- W2081713292 creator A5017295964 @default.
- W2081713292 creator A5044769951 @default.
- W2081713292 creator A5077382508 @default.
- W2081713292 creator A5081279185 @default.
- W2081713292 date "2009-10-01" @default.
- W2081713292 modified "2023-10-12" @default.
- W2081713292 title "Leptin accelerates pronuclear formation following intracytoplasmic sperm injection of porcine oocytes: Possible role for MAP kinase inactivation" @default.
- W2081713292 cites W1967459937 @default.
- W2081713292 cites W1977095479 @default.
- W2081713292 cites W1996713062 @default.
- W2081713292 cites W2011450104 @default.
- W2081713292 cites W2046336403 @default.
- W2081713292 cites W2054734305 @default.
- W2081713292 cites W2055956383 @default.
- W2081713292 cites W2061988277 @default.
- W2081713292 cites W2073828263 @default.
- W2081713292 cites W2075906628 @default.
- W2081713292 cites W2080628130 @default.
- W2081713292 cites W2080960719 @default.
- W2081713292 cites W2083665321 @default.
- W2081713292 cites W2090977677 @default.
- W2081713292 cites W2093163832 @default.
- W2081713292 cites W2099622050 @default.
- W2081713292 cites W2102435911 @default.
- W2081713292 cites W2104408900 @default.
- W2081713292 cites W2122340097 @default.
- W2081713292 cites W2123713118 @default.
- W2081713292 cites W2128727554 @default.
- W2081713292 cites W2132150742 @default.
- W2081713292 cites W2132687570 @default.
- W2081713292 cites W2133307826 @default.
- W2081713292 cites W2140181523 @default.
- W2081713292 cites W2151304633 @default.
- W2081713292 cites W2151409671 @default.
- W2081713292 cites W2152851099 @default.
- W2081713292 cites W2157572727 @default.
- W2081713292 cites W2158155497 @default.
- W2081713292 cites W2161821820 @default.
- W2081713292 cites W2162959052 @default.
- W2081713292 cites W2210150511 @default.
- W2081713292 cites W2562715757 @default.
- W2081713292 cites W4239199795 @default.
- W2081713292 cites W4249875120 @default.
- W2081713292 cites W6013967 @default.
- W2081713292 doi "https://doi.org/10.1016/j.anireprosci.2008.10.021" @default.
- W2081713292 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19100691" @default.
- W2081713292 hasPublicationYear "2009" @default.
- W2081713292 type Work @default.
- W2081713292 sameAs 2081713292 @default.
- W2081713292 citedByCount "19" @default.
- W2081713292 countsByYear W20817132922012 @default.
- W2081713292 countsByYear W20817132922013 @default.
- W2081713292 countsByYear W20817132922014 @default.
- W2081713292 countsByYear W20817132922015 @default.
- W2081713292 countsByYear W20817132922016 @default.
- W2081713292 countsByYear W20817132922018 @default.
- W2081713292 countsByYear W20817132922019 @default.
- W2081713292 countsByYear W20817132922020 @default.
- W2081713292 countsByYear W20817132922021 @default.
- W2081713292 countsByYear W20817132922022 @default.
- W2081713292 crossrefType "journal-article" @default.
- W2081713292 hasAuthorship W2081713292A5017295964 @default.
- W2081713292 hasAuthorship W2081713292A5044769951 @default.
- W2081713292 hasAuthorship W2081713292A5077382508 @default.
- W2081713292 hasAuthorship W2081713292A5081279185 @default.
- W2081713292 hasConcept C105702510 @default.
- W2081713292 hasConcept C126322002 @default.
- W2081713292 hasConcept C134018914 @default.
- W2081713292 hasConcept C16685009 @default.
- W2081713292 hasConcept C179265757 @default.
- W2081713292 hasConcept C185592680 @default.
- W2081713292 hasConcept C196843134 @default.
- W2081713292 hasConcept C201604863 @default.
- W2081713292 hasConcept C2776690073 @default.
- W2081713292 hasConcept C2778177303 @default.
- W2081713292 hasConcept C2778278907 @default.
- W2081713292 hasConcept C2780613262 @default.
- W2081713292 hasConcept C511355011 @default.
- W2081713292 hasConcept C512716672 @default.
- W2081713292 hasConcept C71924100 @default.
- W2081713292 hasConcept C86803240 @default.
- W2081713292 hasConcept C87073359 @default.
- W2081713292 hasConcept C88972607 @default.
- W2081713292 hasConcept C95444343 @default.
- W2081713292 hasConceptScore W2081713292C105702510 @default.
- W2081713292 hasConceptScore W2081713292C126322002 @default.
- W2081713292 hasConceptScore W2081713292C134018914 @default.
- W2081713292 hasConceptScore W2081713292C16685009 @default.
- W2081713292 hasConceptScore W2081713292C179265757 @default.
- W2081713292 hasConceptScore W2081713292C185592680 @default.
- W2081713292 hasConceptScore W2081713292C196843134 @default.
- W2081713292 hasConceptScore W2081713292C201604863 @default.
- W2081713292 hasConceptScore W2081713292C2776690073 @default.
- W2081713292 hasConceptScore W2081713292C2778177303 @default.
- W2081713292 hasConceptScore W2081713292C2778278907 @default.
- W2081713292 hasConceptScore W2081713292C2780613262 @default.