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- W2081716404 abstract "Three nitroparaffins (nitroethane, 1-nitropropane, and 2-nitropropane) were studied in the Salmonella typhimurium/mammalian microsome (Ames) test, with and without microsomal activation systems. Nitroethane and 2-nitropropane also were studied in an in vivo mutagenic (micronucleus) test. These studies were undertaken because these solvents are widely used in the chemical and pharmaceutical industries and 2-nitropropane was reported to cause liver cancer in rats exposed by the inhalation route. Neither nitroethane nor 1-nitropropane was active in the Ames test with Salmonella tester-strains TA1537, TA92, TA98, or TA100. However, 2-nitropropane produced a significant increase in revertants in all of these tester strains, particularly strain TA100, where 3 microliter/plate doubled the number of revertants in the presence of microsomal enzymes. Negative results were obtained with both nitroethane and 2-nitropropane in micronucleus tests. These studies have shown that 2-nitropropane has the potential for causing point mutations in a microbial test system. However, this compound probably will not cause a chromosome mutation of the clastogenic type." @default.
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- W2081716404 date "1979-01-01" @default.
- W2081716404 modified "2023-10-08" @default.
- W2081716404 title "Mutagenic evaluation of nitroparaffins in the salmonella typhimurium/mammalian-microsome test and the micronucleus test" @default.
- W2081716404 cites W1973195696 @default.
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- W2081716404 doi "https://doi.org/10.1002/em.2860010411" @default.
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