Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081725087> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2081725087 endingPage "88" @default.
- W2081725087 startingPage "79" @default.
- W2081725087 abstract "The goal of this study was to explore the signaling pathway regulating the processing of proADAM17 into ADAM17 in Taiwan cobra phospholipase A2 (PLA2)-treated human leukemia U937 cells. PLA2 induced reactive oxygen species (ROS)-elicited p38 MAPK activation and ERK inactivation in U937 cells. Catalytically inactive bromophenacylated PLA2 (BPB-PLA2) and PLA2 mutants evoked Ca2+-mediated p38 MAPK activation, and the level of phosphorylated ERK remained unchanged. PLA2 treatment reduced mature ADAM17 expression and secreted TNF-α (sTNF-α) production. Co-treatment of SB202190 (p38 MAPK inhibitor) and catalytically inactive PLA2 increased ERK phosphorylation, ADAM17 maturation and sTNF-α production. Nevertheless, mRNA levels of ADAM17 and TNF-α were insignificantly altered after PLA2 and SB202190/BPB-PLA2 treatment. ADAM17 activity assay and knock-down of ADAM17 revealed that ADAM17 was involved in sTNF-α production. Restoration of ERK activation increased the processing of proADAM17 into ADAM17 in PLA2-treated cells, while inactivation of ERK reduced ADAM17 maturation in untreated and SB202190/BPB-PLA2-treated cells. Removal of cell surface heparan sulfate abrogated PLA2 and SB202190/BPB-PLA2 effect on ADAM17 maturation. Taken together, the present data reveal that PLA2 suppresses ERK-mediated ADAM17 maturation, thus reducing sTNF-α production in U937 cells. Moreover, the binding with heparan sulfate is crucial for the PLA2 effect." @default.
- W2081725087 created "2016-06-24" @default.
- W2081725087 creator A5026887457 @default.
- W2081725087 creator A5026894870 @default.
- W2081725087 creator A5047258498 @default.
- W2081725087 creator A5058012551 @default.
- W2081725087 creator A5058679821 @default.
- W2081725087 creator A5078226445 @default.
- W2081725087 date "2014-08-01" @default.
- W2081725087 modified "2023-10-06" @default.
- W2081725087 title "Taiwan cobra phospholipase A2 suppresses ERK-mediated ADAM17 maturation, thus reducing secreted TNF-α production in human leukemia U937 cells" @default.
- W2081725087 cites W1882946118 @default.
- W2081725087 cites W1969915666 @default.
- W2081725087 cites W1970458434 @default.
- W2081725087 cites W1975910343 @default.
- W2081725087 cites W1979561566 @default.
- W2081725087 cites W1993174240 @default.
- W2081725087 cites W2012209630 @default.
- W2081725087 cites W2014262085 @default.
- W2081725087 cites W2019865982 @default.
- W2081725087 cites W2031380343 @default.
- W2081725087 cites W2031499670 @default.
- W2081725087 cites W2036731620 @default.
- W2081725087 cites W2046415562 @default.
- W2081725087 cites W2047975987 @default.
- W2081725087 cites W2048356493 @default.
- W2081725087 cites W2051986345 @default.
- W2081725087 cites W2052022512 @default.
- W2081725087 cites W2058062440 @default.
- W2081725087 cites W2060362541 @default.
- W2081725087 cites W2063502161 @default.
- W2081725087 cites W2066150943 @default.
- W2081725087 cites W2072647758 @default.
- W2081725087 cites W2084929462 @default.
- W2081725087 cites W2091583316 @default.
- W2081725087 cites W2091902048 @default.
- W2081725087 cites W2093506260 @default.
- W2081725087 cites W2093768782 @default.
- W2081725087 cites W2145837099 @default.
- W2081725087 cites W2150040843 @default.
- W2081725087 doi "https://doi.org/10.1016/j.toxicon.2014.05.012" @default.
- W2081725087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24874889" @default.
- W2081725087 hasPublicationYear "2014" @default.
- W2081725087 type Work @default.
- W2081725087 sameAs 2081725087 @default.
- W2081725087 citedByCount "1" @default.
- W2081725087 countsByYear W20817250872016 @default.
- W2081725087 crossrefType "journal-article" @default.
- W2081725087 hasAuthorship W2081725087A5026887457 @default.
- W2081725087 hasAuthorship W2081725087A5026894870 @default.
- W2081725087 hasAuthorship W2081725087A5047258498 @default.
- W2081725087 hasAuthorship W2081725087A5058012551 @default.
- W2081725087 hasAuthorship W2081725087A5058679821 @default.
- W2081725087 hasAuthorship W2081725087A5078226445 @default.
- W2081725087 hasConcept C108634530 @default.
- W2081725087 hasConcept C11960822 @default.
- W2081725087 hasConcept C181199279 @default.
- W2081725087 hasConcept C185592680 @default.
- W2081725087 hasConcept C190283241 @default.
- W2081725087 hasConcept C2776551241 @default.
- W2081725087 hasConcept C48349386 @default.
- W2081725087 hasConcept C51551487 @default.
- W2081725087 hasConcept C55493867 @default.
- W2081725087 hasConcept C57074206 @default.
- W2081725087 hasConcept C86803240 @default.
- W2081725087 hasConcept C95444343 @default.
- W2081725087 hasConceptScore W2081725087C108634530 @default.
- W2081725087 hasConceptScore W2081725087C11960822 @default.
- W2081725087 hasConceptScore W2081725087C181199279 @default.
- W2081725087 hasConceptScore W2081725087C185592680 @default.
- W2081725087 hasConceptScore W2081725087C190283241 @default.
- W2081725087 hasConceptScore W2081725087C2776551241 @default.
- W2081725087 hasConceptScore W2081725087C48349386 @default.
- W2081725087 hasConceptScore W2081725087C51551487 @default.
- W2081725087 hasConceptScore W2081725087C55493867 @default.
- W2081725087 hasConceptScore W2081725087C57074206 @default.
- W2081725087 hasConceptScore W2081725087C86803240 @default.
- W2081725087 hasConceptScore W2081725087C95444343 @default.
- W2081725087 hasLocation W20817250871 @default.
- W2081725087 hasLocation W20817250872 @default.
- W2081725087 hasOpenAccess W2081725087 @default.
- W2081725087 hasPrimaryLocation W20817250871 @default.
- W2081725087 hasRelatedWork W196367670 @default.
- W2081725087 hasRelatedWork W1979464515 @default.
- W2081725087 hasRelatedWork W2029614856 @default.
- W2081725087 hasRelatedWork W2034225929 @default.
- W2081725087 hasRelatedWork W2069269450 @default.
- W2081725087 hasRelatedWork W2106969175 @default.
- W2081725087 hasRelatedWork W2336184425 @default.
- W2081725087 hasRelatedWork W2434641497 @default.
- W2081725087 hasRelatedWork W2978781268 @default.
- W2081725087 hasRelatedWork W3118287616 @default.
- W2081725087 hasVolume "86" @default.
- W2081725087 isParatext "false" @default.
- W2081725087 isRetracted "false" @default.
- W2081725087 magId "2081725087" @default.
- W2081725087 workType "article" @default.