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• W2081728497 abstract "Abstract: Impaired Ca 2+ homeostasis and smooth muscle contractility co‐exist in acute cholecystitis (AC) leading to gallbladder dysfunction. There is no pharmacological treatment for this pathological condition. Our aim was to evaluate the effects of melatonin treatment on Ca 2+ signaling pathways and contractility altered by cholecystitis. [Ca 2+ ] i was determined by epifluorescence microscopy in fura‐2 loaded isolated gallbladder smooth muscle cells, and isometric tension was recorded from gallbladder muscle strips. Malondialdehyde (MDA) and reduced glutathione (GSH) contents were determined by spectrophotometry and cycloxygenase‐2 (COX‐2) expression was quantified by western blot. Melatonin was tested in two experimental groups, one of which underwent common bile duct ligation for 2 days and another that was later de‐ligated for 2 days. Inflammation‐induced impairment of Ca 2+ responses to cholecystokinin and caffeine were recovered by melatonin treatment (30 mg/kg). This treatment also ameliorated the detrimental effects of AC on Ca 2+ influx through both L‐type and capacitative Ca 2+ channels, and it was effective in preserving the pharmacological phenotype of these channels. Despite its effects on Ca 2+ homeostasis, melatonin did not improve contractility. After de‐ligation, Ca 2+ influx and contractility were still impaired, but both were recovered by melatonin. These effects of melatonin were associated to a reduction of MDA levels, an increase in GSH content and a decrease in COX‐2 expression. These findings indicate that melatonin restores Ca 2+ homeostasis during AC and resolves inflammation. In addition, this indoleamine helps in the subsequent recovery of functionality." @default.
• W2081728497 created "2016-06-24" @default.
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• W2081728497 date "2007-10-23" @default.
• W2081728497 modified "2023-10-18" @default.
• W2081728497 title "Protective effect of melatonin on Ca²⁺homeostasis and contractility in acute cholecystitis" @default.
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• W2081728497 doi "https://doi.org/10.1111/j.1600-079x.2007.00520.x" @default.
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