FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081742283> ?p ?o ?g. }

• W2081742283 endingPage "237" @default.
• W2081742283 startingPage "228" @default.
• W2081742283 abstract "In animal models of neuropathic pain, transection or constrictive injury to peripheral nerves produces ectopic discharges originating at both injury sites and related dorsal root ganglia (DRG). In addition, hyperexcitability is observed in associated dorsal horn (DH) neurons of the spinal cord. As ectopic discharges are inhibited by agents that block voltage-sensitive Na+ channels, it has been postulated that accumulation of Na+ channels in the membrane at nerve injury sites may contribute to the development of ectopic nerve activity (ENA). The goal of the present study was to compare the sensitivity of ENA to lidocaine and QX-314, a positively charged lidocaine derivative, which is frequently assumed to be membrane impermeant. Experiments were performed on adult male Sprague–Dawley rats in which the common sciatic nerve had been transected 4–10 days earlier. Extracellular microelectrode recordings were made from DRG and DH neurons, and neuromal activity was measured in fine bundles of microfilaments teased from sciatic nerves in anesthetized and paralyzed rats. Comparative effects on heart rate (HR) and mean blood pressure (MBP) were also studied. To confirm that externally applied QX-314 is able to inhibit high frequency activity in sensory nerves, QX-314 was superfused over isolated rat vagus nerves during stimulation of compound action potentials in C-fibers (C-spikes). As expected, intravenously administered lidocaine inhibited ENA at all three sites. Lidocaine ED50 values (expressed as mg/kg, with 95% confidence limits) were: 10.2 (7.8–13.3), 1.4 (0.8–2.4) and 0.9 (0.4–2.0) for neuromas, DRG and DH neurons, respectively. QX-314 also induced dose-dependent inhibition of ENA at neuromas and DRG, but produced only a small inhibition of DH neuron ENA. QX-314 had the following ED50 values (mg/kg) for neuromas, DRG and DH neurons, respectively: 2.3 (2.0–2.8), 6.9 (4.7–26.5) and 85.7. QX-314-mediated inhibition of DRG ENA had a slow onset and was long-lasting, relative to lidocaine. Lidocaine or QX-314 also significantly reduced HR and MBP in the same dose range as that which reduced ENA in DRG or neuromas. In isolated rat vagus nerve recordings, QX-314 induced marked use-dependent inhibition of C-spike amplitude, with IC50 values (μM) of 9000 (4600–18 000) and 350 (290–420) for low- (0.03 Hz) and high-frequency (30 Hz) C-spikes, respectively. These data support the hypothesis that Na+ channel accumulation contributes to the generation of ectopic discharges in neuromas and DRG, and suggests that intravenous QX-314 can acutely block Na+ channels at these sites." @default.
• W2081742283 created "2016-06-24" @default.
• W2081742283 creator A5026950758 @default.
• W2081742283 creator A5039306494 @default.
• W2081742283 creator A5048366671 @default.
• W2081742283 creator A5078255099 @default.
• W2081742283 date "1997-10-01" @default.
• W2081742283 modified "2023-10-14" @default.
• W2081742283 title "QX-314 inhibits ectopic nerve activity associated with neuropathic pain" @default.
• W2081742283 cites W1499426773 @default.
• W2081742283 cites W1759966863 @default.
• W2081742283 cites W1822822588 @default.
• W2081742283 cites W1966133272 @default.
• W2081742283 cites W1971936787 @default.
• W2081742283 cites W1973306320 @default.
• W2081742283 cites W1977774988 @default.
• W2081742283 cites W1980155039 @default.
• W2081742283 cites W1985465562 @default.
• W2081742283 cites W1988963823 @default.
• W2081742283 cites W1990360679 @default.
• W2081742283 cites W1995460017 @default.
• W2081742283 cites W1996180460 @default.
• W2081742283 cites W1997472615 @default.
• W2081742283 cites W2005286314 @default.
• W2081742283 cites W2017724266 @default.
• W2081742283 cites W2019406234 @default.
• W2081742283 cites W2020776282 @default.
• W2081742283 cites W2021478036 @default.
• W2081742283 cites W2024012135 @default.
• W2081742283 cites W2029376214 @default.
• W2081742283 cites W2034595944 @default.
• W2081742283 cites W2038945391 @default.
• W2081742283 cites W2038996387 @default.
• W2081742283 cites W2048426342 @default.
• W2081742283 cites W2048656464 @default.
• W2081742283 cites W2058020736 @default.
• W2081742283 cites W2075419292 @default.
• W2081742283 cites W2076696791 @default.
• W2081742283 cites W2081162866 @default.
• W2081742283 cites W2081533056 @default.
• W2081742283 cites W2081566651 @default.
• W2081742283 cites W2083340810 @default.
• W2081742283 cites W2245561430 @default.
• W2081742283 cites W2409860536 @default.
• W2081742283 cites W58784892 @default.
• W2081742283 doi "https://doi.org/10.1016/s0006-8993(97)00770-1" @default.
• W2081742283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9401743" @default.
• W2081742283 hasPublicationYear "1997" @default.
• W2081742283 type Work @default.
• W2081742283 sameAs 2081742283 @default.
• W2081742283 citedByCount "84" @default.
• W2081742283 countsByYear W20817422832012 @default.
• W2081742283 countsByYear W20817422832013 @default.
• W2081742283 countsByYear W20817422832014 @default.
• W2081742283 countsByYear W20817422832016 @default.
• W2081742283 countsByYear W20817422832017 @default.
• W2081742283 countsByYear W20817422832019 @default.
• W2081742283 countsByYear W20817422832022 @default.
• W2081742283 crossrefType "journal-article" @default.
• W2081742283 hasAuthorship W2081742283A5026950758 @default.
• W2081742283 hasAuthorship W2081742283A5039306494 @default.
• W2081742283 hasAuthorship W2081742283A5048366671 @default.
• W2081742283 hasAuthorship W2081742283A5078255099 @default.
• W2081742283 hasConcept C105702510 @default.
• W2081742283 hasConcept C118552586 @default.
• W2081742283 hasConcept C126322002 @default.
• W2081742283 hasConcept C15490471 @default.
• W2081742283 hasConcept C170493617 @default.
• W2081742283 hasConcept C185592680 @default.
• W2081742283 hasConcept C24998067 @default.
• W2081742283 hasConcept C2775991916 @default.
• W2081742283 hasConcept C2777107010 @default.
• W2081742283 hasConcept C2780149897 @default.
• W2081742283 hasConcept C2780775167 @default.
• W2081742283 hasConcept C2781149210 @default.
• W2081742283 hasConcept C2781404750 @default.
• W2081742283 hasConcept C42219234 @default.
• W2081742283 hasConcept C71924100 @default.
• W2081742283 hasConceptScore W2081742283C105702510 @default.
• W2081742283 hasConceptScore W2081742283C118552586 @default.
• W2081742283 hasConceptScore W2081742283C126322002 @default.
• W2081742283 hasConceptScore W2081742283C15490471 @default.
• W2081742283 hasConceptScore W2081742283C170493617 @default.
• W2081742283 hasConceptScore W2081742283C185592680 @default.
• W2081742283 hasConceptScore W2081742283C24998067 @default.
• W2081742283 hasConceptScore W2081742283C2775991916 @default.
• W2081742283 hasConceptScore W2081742283C2777107010 @default.
• W2081742283 hasConceptScore W2081742283C2780149897 @default.
• W2081742283 hasConceptScore W2081742283C2780775167 @default.
• W2081742283 hasConceptScore W2081742283C2781149210 @default.
• W2081742283 hasConceptScore W2081742283C2781404750 @default.
• W2081742283 hasConceptScore W2081742283C42219234 @default.
• W2081742283 hasConceptScore W2081742283C71924100 @default.
• W2081742283 hasIssue "2" @default.
• W2081742283 hasLocation W20817422831 @default.
• W2081742283 hasLocation W20817422832 @default.
• W2081742283 hasOpenAccess W2081742283 @default.
• W2081742283 hasPrimaryLocation W20817422831 @default.

• next