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• W2081746875 abstract "Neurons in the nodose ganglion were enzymatically dissociated from adult rabbits and electrophysiologically examined within 2 h. About 90% of the neurons survived the dissociation procedure. Their resting membrane potential (−59 ± 0.6 mV), time constant (5.7 ± 0.5 ms), input resistance (80 ± 5.3 MΩ), action potential properties (amplitude, 79 ± 1.2 mV; overshoot 21 ± 1 0 mV; duration 5.2 ± 0.1 ms; threshold, −38 ± 0.9 mV; and fast spike afterhyperpolarizaton, 10 ± 0.5 mV, 64 ± 3.8 ms) were not different from values obtained from nodose neurons in intact ganglion in vitro and in vivo. An unusually long duration spike afterhyperpolarization observed in about 35% of nodose neurons in intact ganglion was demonstrated in about 28% of the acutely isolated neurons. The percentage of isolated neurons responding to bath applied acetylcholine, bradykinin, serotonin and histamine was similar to those reported for neurons in the intact ganglia. We conclude that the electrophysiological and chemoreceptive properties of acutely isolated adult rabbit nodose neurons are similar to those observed for neurons in intact ganglia. Thus the availability of large numbers of acutely isolated adult nodose neurons should allow multidisciplinary studies of vagal afferent C-fiber neurons not readily obtainable in the intact ganglion." @default.
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• W2081746875 date "1993-10-01" @default.
• W2081746875 modified "2023-10-02" @default.
• W2081746875 title "Electrophysiological properties and chemosensitivity of acutely isolated nodose ganglion neurons of the rabbit" @default.
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• W2081746875 doi "https://doi.org/10.1016/0165-1838(93)90359-3" @default.
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