Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081760508> ?p ?o ?g. }
- W2081760508 endingPage "124" @default.
- W2081760508 startingPage "119" @default.
- W2081760508 abstract "Ras GTPase‑activating protein 1 (RASA1) functions to inactivate Ras‑GTPase and inhibit the mitogenic signal. Reduction or loss of RASA1 expression occurs during human cancer development and progression. This study investigated RASA1 expression in normal and breast cancer tissue specimens to determine the association with prognosis of breast cancer patients. Two sets of patient samples (45 fresh tissues and 373 paraffin‑embedded tissues) were analyzed for RASA1 expression using RT‑qPCR and immunohisto-chemistry. The results showed that the expression of RASA1 mRNA was lower in breast cancer tissues than in the corresponding normal tissues (P<0.001). Additionally, RASA1 expression was reduced in 60.6% (226/373) of breast cancer tissues. The reduced RASA1 expression was significantly associated with tumor lymph node metastasis (P=0.002), advanced TNM stages (P=0.017), estrogen receptor (ER) expression (P=0.002), Ki‑67 (P=0.009), higher histological grade (P<0.001), and triple‑negative breast cancer (P=0.041). Moreover, the reduced RASA1 expression was associated with shorter disease‑free survival (P=0.036) and overall survival (P<0.001) of breast cancer patients. RASA1 expression, together with tumor lymph‑node metastasis, TNM stage, Her‑2 expression, and triple‑negative breast cancer were independent factors in predicting survival of breast cancer patients. In conclusion, RASA1 expression is frequently reduced in breast cancer tissues, and the reduced RASA1 expression is associated with breast cancer progression and poor survival and disease‑free survival of patients." @default.
- W2081760508 created "2016-06-24" @default.
- W2081760508 creator A5001547762 @default.
- W2081760508 creator A5029882239 @default.
- W2081760508 creator A5032244728 @default.
- W2081760508 creator A5046775442 @default.
- W2081760508 creator A5063273603 @default.
- W2081760508 creator A5086855515 @default.
- W2081760508 date "2014-11-13" @default.
- W2081760508 modified "2023-09-30" @default.
- W2081760508 title "Downregulation of Ras GTPase-activating protein 1 is associated with poor survival of breast invasive ductal carcinoma patients" @default.
- W2081760508 cites W1764066647 @default.
- W2081760508 cites W1909400967 @default.
- W2081760508 cites W1965747240 @default.
- W2081760508 cites W1976360756 @default.
- W2081760508 cites W1976500266 @default.
- W2081760508 cites W1979646488 @default.
- W2081760508 cites W1988803183 @default.
- W2081760508 cites W1995224853 @default.
- W2081760508 cites W2017352211 @default.
- W2081760508 cites W2026075246 @default.
- W2081760508 cites W2041030848 @default.
- W2081760508 cites W2043866509 @default.
- W2081760508 cites W2051958752 @default.
- W2081760508 cites W2060901213 @default.
- W2081760508 cites W2064133381 @default.
- W2081760508 cites W2071018921 @default.
- W2081760508 cites W2072930635 @default.
- W2081760508 cites W2074620545 @default.
- W2081760508 cites W2075643909 @default.
- W2081760508 cites W2080287591 @default.
- W2081760508 cites W2089375674 @default.
- W2081760508 cites W2096238248 @default.
- W2081760508 cites W2100061812 @default.
- W2081760508 cites W2101599060 @default.
- W2081760508 cites W2118605519 @default.
- W2081760508 cites W2120694934 @default.
- W2081760508 cites W2127057139 @default.
- W2081760508 cites W2154458783 @default.
- W2081760508 cites W2157285286 @default.
- W2081760508 cites W2157976923 @default.
- W2081760508 cites W2162401315 @default.
- W2081760508 cites W2167897415 @default.
- W2081760508 doi "https://doi.org/10.3892/or.2014.3604" @default.
- W2081760508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25394563" @default.
- W2081760508 hasPublicationYear "2014" @default.
- W2081760508 type Work @default.
- W2081760508 sameAs 2081760508 @default.
- W2081760508 citedByCount "13" @default.
- W2081760508 countsByYear W20817605082016 @default.
- W2081760508 countsByYear W20817605082017 @default.
- W2081760508 countsByYear W20817605082019 @default.
- W2081760508 countsByYear W20817605082020 @default.
- W2081760508 countsByYear W20817605082021 @default.
- W2081760508 crossrefType "journal-article" @default.
- W2081760508 hasAuthorship W2081760508A5001547762 @default.
- W2081760508 hasAuthorship W2081760508A5029882239 @default.
- W2081760508 hasAuthorship W2081760508A5032244728 @default.
- W2081760508 hasAuthorship W2081760508A5046775442 @default.
- W2081760508 hasAuthorship W2081760508A5063273603 @default.
- W2081760508 hasAuthorship W2081760508A5086855515 @default.
- W2081760508 hasBestOaLocation W20817605081 @default.
- W2081760508 hasConcept C111683008 @default.
- W2081760508 hasConcept C118646709 @default.
- W2081760508 hasConcept C121608353 @default.
- W2081760508 hasConcept C126322002 @default.
- W2081760508 hasConcept C143998085 @default.
- W2081760508 hasConcept C2779013556 @default.
- W2081760508 hasConcept C2781018059 @default.
- W2081760508 hasConcept C29537977 @default.
- W2081760508 hasConcept C3018521938 @default.
- W2081760508 hasConcept C502942594 @default.
- W2081760508 hasConcept C530470458 @default.
- W2081760508 hasConcept C555283112 @default.
- W2081760508 hasConcept C67082663 @default.
- W2081760508 hasConcept C71924100 @default.
- W2081760508 hasConcept C84606932 @default.
- W2081760508 hasConcept C86803240 @default.
- W2081760508 hasConceptScore W2081760508C111683008 @default.
- W2081760508 hasConceptScore W2081760508C118646709 @default.
- W2081760508 hasConceptScore W2081760508C121608353 @default.
- W2081760508 hasConceptScore W2081760508C126322002 @default.
- W2081760508 hasConceptScore W2081760508C143998085 @default.
- W2081760508 hasConceptScore W2081760508C2779013556 @default.
- W2081760508 hasConceptScore W2081760508C2781018059 @default.
- W2081760508 hasConceptScore W2081760508C29537977 @default.
- W2081760508 hasConceptScore W2081760508C3018521938 @default.
- W2081760508 hasConceptScore W2081760508C502942594 @default.
- W2081760508 hasConceptScore W2081760508C530470458 @default.
- W2081760508 hasConceptScore W2081760508C555283112 @default.
- W2081760508 hasConceptScore W2081760508C67082663 @default.
- W2081760508 hasConceptScore W2081760508C71924100 @default.
- W2081760508 hasConceptScore W2081760508C84606932 @default.
- W2081760508 hasConceptScore W2081760508C86803240 @default.
- W2081760508 hasIssue "1" @default.
- W2081760508 hasLocation W20817605081 @default.
- W2081760508 hasLocation W20817605082 @default.
- W2081760508 hasOpenAccess W2081760508 @default.