Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081766813> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2081766813 endingPage "210" @default.
- W2081766813 startingPage "203" @default.
- W2081766813 abstract "The members of a series of 1-alkylcarbonyl-5-FU prodrug derivatives have been characterized and evaluated for their abilities to deliver 5-FU into and through skin. There was no correlation of lipid solubility or partition coefficient with relative abilities of the members of the 1-alkylcarbonyl series to deliver 5-FU through skin. However, there was a correlation with water solubility within the series. Although their lipid solubilities and partition coefficient values were greater than those of the 1-alkyloxycarbonyl series, only 1-acetyl-5-FU was more soluble in water, and only 1-acetyl-5-FU delivered more total 5-FU species through the skin than the corresponding member of the 1-alkyloxycarbonyl series. On the other hand, the 1-alkylcarbonyl series was more effective at enhancing the ratio of dermal to transdermal delivery (D/T delivery ratio) than the 1-alkyloxycarbonyl series, presumably because of the rapid hydrolysis of the members of the former series once contact with the aqueous domains of the epidermis had been made. Thus, the hypothesis that enhanced D/T delivery ratio requires rapid hydrolysis of the prodrug after it partitions into the skin is supported. Although the prodrugs hydrolyzed rapidly in water, they were stable in isopropyl myristate (IPM) during their application in IPM to highly hydrated skin. There was also a good correlation of calculated solubility parameters for the prodrugs with their permeability coefficients." @default.
- W2081766813 created "2016-06-24" @default.
- W2081766813 creator A5003922767 @default.
- W2081766813 creator A5064269569 @default.
- W2081766813 date "1996-03-01" @default.
- W2081766813 modified "2023-09-23" @default.
- W2081766813 title "Transdermal delivery of 5-fluorouracil (5-FU) by 1-alkylcarbonyl-5-FU prodrugs" @default.
- W2081766813 cites W1976559502 @default.
- W2081766813 cites W1978143129 @default.
- W2081766813 cites W1980977381 @default.
- W2081766813 cites W1983819655 @default.
- W2081766813 cites W2005787232 @default.
- W2081766813 cites W2040866523 @default.
- W2081766813 cites W2054384204 @default.
- W2081766813 cites W2071953730 @default.
- W2081766813 cites W2095146304 @default.
- W2081766813 cites W2118372038 @default.
- W2081766813 cites W2144084595 @default.
- W2081766813 cites W4236353098 @default.
- W2081766813 cites W4249540270 @default.
- W2081766813 cites W4252111711 @default.
- W2081766813 cites W1969027250 @default.
- W2081766813 doi "https://doi.org/10.1016/0378-5173(95)04327-6" @default.
- W2081766813 hasPublicationYear "1996" @default.
- W2081766813 type Work @default.
- W2081766813 sameAs 2081766813 @default.
- W2081766813 citedByCount "35" @default.
- W2081766813 countsByYear W20817668132013 @default.
- W2081766813 countsByYear W20817668132014 @default.
- W2081766813 countsByYear W20817668132015 @default.
- W2081766813 countsByYear W20817668132016 @default.
- W2081766813 countsByYear W20817668132018 @default.
- W2081766813 countsByYear W20817668132019 @default.
- W2081766813 crossrefType "journal-article" @default.
- W2081766813 hasAuthorship W2081766813A5003922767 @default.
- W2081766813 hasAuthorship W2081766813A5064269569 @default.
- W2081766813 hasConcept C108215921 @default.
- W2081766813 hasConcept C155574463 @default.
- W2081766813 hasConcept C178790620 @default.
- W2081766813 hasConcept C184651966 @default.
- W2081766813 hasConcept C185592680 @default.
- W2081766813 hasConcept C192552737 @default.
- W2081766813 hasConcept C201399114 @default.
- W2081766813 hasConcept C205679159 @default.
- W2081766813 hasConcept C2779783494 @default.
- W2081766813 hasConcept C43617362 @default.
- W2081766813 hasConcept C55493867 @default.
- W2081766813 hasConcept C71924100 @default.
- W2081766813 hasConcept C94412978 @default.
- W2081766813 hasConcept C98274493 @default.
- W2081766813 hasConceptScore W2081766813C108215921 @default.
- W2081766813 hasConceptScore W2081766813C155574463 @default.
- W2081766813 hasConceptScore W2081766813C178790620 @default.
- W2081766813 hasConceptScore W2081766813C184651966 @default.
- W2081766813 hasConceptScore W2081766813C185592680 @default.
- W2081766813 hasConceptScore W2081766813C192552737 @default.
- W2081766813 hasConceptScore W2081766813C201399114 @default.
- W2081766813 hasConceptScore W2081766813C205679159 @default.
- W2081766813 hasConceptScore W2081766813C2779783494 @default.
- W2081766813 hasConceptScore W2081766813C43617362 @default.
- W2081766813 hasConceptScore W2081766813C55493867 @default.
- W2081766813 hasConceptScore W2081766813C71924100 @default.
- W2081766813 hasConceptScore W2081766813C94412978 @default.
- W2081766813 hasConceptScore W2081766813C98274493 @default.
- W2081766813 hasIssue "1-2" @default.
- W2081766813 hasLocation W20817668131 @default.
- W2081766813 hasOpenAccess W2081766813 @default.
- W2081766813 hasPrimaryLocation W20817668131 @default.
- W2081766813 hasRelatedWork W1963831149 @default.
- W2081766813 hasRelatedWork W2011594031 @default.
- W2081766813 hasRelatedWork W2012466429 @default.
- W2081766813 hasRelatedWork W2019932867 @default.
- W2081766813 hasRelatedWork W2044823891 @default.
- W2081766813 hasRelatedWork W2087925954 @default.
- W2081766813 hasRelatedWork W2091353596 @default.
- W2081766813 hasRelatedWork W2135953058 @default.
- W2081766813 hasRelatedWork W2187839513 @default.
- W2081766813 hasRelatedWork W4252111711 @default.
- W2081766813 hasVolume "129" @default.
- W2081766813 isParatext "false" @default.
- W2081766813 isRetracted "false" @default.
- W2081766813 magId "2081766813" @default.
- W2081766813 workType "article" @default.