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• W2081767905 abstract "We describe here Ro 46-8443, the first non-peptide endothelin ETB receptor selective antagonist. It displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. The observed parallel rightward shift of concentration-response curves with different antagonist concentrations is consistent with a competitive binding mode. Since R0 46-8443 selectively inhibits ETB receptor mediated responses, it is a valuable tool for clarifying the role of ETB receptors in pathology." @default.
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• W2081767905 date "1996-03-25" @default.
• W2081767905 modified "2023-10-17" @default.
• W2081767905 title "In vitro characterisation of Ro 46-8443, the first non-peptide antagonist selective for the endothelin ET_Breceptor" @default.
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• W2081767905 doi "https://doi.org/10.1016/0014-5793(96)00213-x" @default.
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