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- W2081771896 abstract "340 The relative low incidence of CMV in pretransplant pediatric patients in comparison to that of adults implies a higher probability of exposure and seroconversion early or late after transplantation. This study focuses on the fate of the previously unexposed pediatric recipient, and intends to determine whether post-transplant seroconversion is associated with a higher incidence of clinical CMV disease. Methods: The pretransplant recipient and donor CMV serological status was determined by detection of CMV IgG by enzyme immunoassay. The study group included 50 pediatric liver recipients ages 2 weeks to 18 years. Routine post-transplant CMV prophylaxis included gammaglobulin or ganciclovir using previously published protocols. Post-transplant CMV status was determined either following clinical findings indicative of possible CMV disease, or as part of the completion of this study. Variables to be examined included the risk of exposure, the rate of seroconversion, and the incidence of clinical CMV disease. Results: The incidence of CMV positive serologies in our pediatric population is 32% (approx. 70% in adults), and is lower in candidates under the age of 5 (19%). CMV seropositivity is high (52%) in the donor pool available for this population, and is not attributed to the increased used of reduced size grafts from seropositive adults (53%) in this series. Of the previously unexposed recipients, seroconversion is observed in 38%, and in the majority (78%), directly related to donor transmission. Of these, only a minority of the seroconverted patients were found to suffer from clinical CMV disease (22%). Conclusions: Pediatric patients under the age of 5 are at high risk for CMV exposure and seroconversion. Frequent post-transplant seroconversion occurs in the majority of these patients and is donor-related transmission or environmental exposure. Despite that, only a small group of immunosuppressed recipients develop CMV disease, a finding that may be attributed to more liberal use of prophylaxis protocols." @default.
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- W2081771896 date "1998-05-01" @default.
- W2081771896 modified "2023-10-18" @default.
- W2081771896 title "VARIABLES AFFECTING THE RISK OF CMV INFECTION OR SEROCONVERSION IN THE UNEXPOSED PEDIATRIC LIVER TRANSPLANT RECIPIENT" @default.
- W2081771896 doi "https://doi.org/10.1097/00007890-199805131-00338" @default.
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