FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081799074> ?p ?o ?g. }

• W2081799074 endingPage "1081" @default.
• W2081799074 startingPage "1071" @default.
• W2081799074 abstract "Developing a new generation of vaccines is important for preventing tuberculosis (TB). DNA vaccine is one promising candidate. In this study we evaluated the immunogenicity and protective efficacy of the DNA vaccine encoding the fusion protein of Mycobacterium tuberculosis heat shock protein 65 (Hsp65) with human interleukin‐2 (hIL‐2) in BALB/c mice. We showed that the DNA vaccine pcDNA‐Hsp65‐hIL‐2 could induce high levels of antigen‐specific antibody, IFN‐γ, CD4 + and CD8 + T cell production. When the immunized mice were infected with M. tuberculosis H37Rv, the organ bacterial loads in the DNA immunized group were significantly reduced compared to those of the saline control group, but the ability to reduce bacteria was not better than for BCG. The histopathology in lungs of the DNA vaccine immunized mice was similar to that of BCG immunized mice, which was obviously ameliorated compared to that of the saline control group. Overall, the DNA vaccine could afford protection against M. tuberculosis infection, though the protection efficacy was not as great as that of conventional BCG." @default.
• W2081799074 created "2016-06-24" @default.
• W2081799074 creator A5000001452 @default.
• W2081799074 creator A5006239432 @default.
• W2081799074 creator A5029598771 @default.
• W2081799074 creator A5029849405 @default.
• W2081799074 creator A5046854745 @default.
• W2081799074 creator A5048369268 @default.
• W2081799074 creator A5074981026 @default.
• W2081799074 date "2008-12-01" @default.
• W2081799074 modified "2023-10-12" @default.
• W2081799074 title "Immunogenicity and protective efficacy of a DNA vaccine encoding the fusion protein of mycobacterium heat shock protein 65(Hsp65) with human interleukin-2 against<i>Mycobacterium tuberculosis</i>in BALB/c mice" @default.
• W2081799074 cites W1512413304 @default.
• W2081799074 cites W1516045899 @default.
• W2081799074 cites W1536595294 @default.
• W2081799074 cites W1592760947 @default.
• W2081799074 cites W1898764189 @default.
• W2081799074 cites W1975045527 @default.
• W2081799074 cites W1991087184 @default.
• W2081799074 cites W1998192441 @default.
• W2081799074 cites W2004279505 @default.
• W2081799074 cites W2022561016 @default.
• W2081799074 cites W2056455854 @default.
• W2081799074 cites W2057033926 @default.
• W2081799074 cites W2066973840 @default.
• W2081799074 cites W2070426326 @default.
• W2081799074 cites W2070803308 @default.
• W2081799074 cites W2075160942 @default.
• W2081799074 cites W2085644212 @default.
• W2081799074 cites W2099952775 @default.
• W2081799074 cites W2103640382 @default.
• W2081799074 cites W2109352986 @default.
• W2081799074 cites W2109484445 @default.
• W2081799074 cites W2112333290 @default.
• W2081799074 cites W2114918609 @default.
• W2081799074 cites W2130046741 @default.
• W2081799074 cites W2144010669 @default.
• W2081799074 cites W2158023121 @default.
• W2081799074 cites W2164252172 @default.
• W2081799074 cites W2184085209 @default.
• W2081799074 cites W4238367009 @default.
• W2081799074 doi "https://doi.org/10.1111/j.1600-0463.2008.01095.x" @default.
• W2081799074 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19133010" @default.
• W2081799074 hasPublicationYear "2008" @default.
• W2081799074 type Work @default.
• W2081799074 sameAs 2081799074 @default.
• W2081799074 citedByCount "6" @default.
• W2081799074 countsByYear W20817990742012 @default.
• W2081799074 countsByYear W20817990742013 @default.
• W2081799074 countsByYear W20817990742018 @default.
• W2081799074 crossrefType "journal-article" @default.
• W2081799074 hasAuthorship W2081799074A5000001452 @default.
• W2081799074 hasAuthorship W2081799074A5006239432 @default.
• W2081799074 hasAuthorship W2081799074A5029598771 @default.
• W2081799074 hasAuthorship W2081799074A5029849405 @default.
• W2081799074 hasAuthorship W2081799074A5046854745 @default.
• W2081799074 hasAuthorship W2081799074A5048369268 @default.
• W2081799074 hasAuthorship W2081799074A5074981026 @default.
• W2081799074 hasConcept C104317684 @default.
• W2081799074 hasConcept C123894998 @default.
• W2081799074 hasConcept C142724271 @default.
• W2081799074 hasConcept C159047783 @default.
• W2081799074 hasConcept C167508917 @default.
• W2081799074 hasConcept C203014093 @default.
• W2081799074 hasConcept C205260736 @default.
• W2081799074 hasConcept C2777975735 @default.
• W2081799074 hasConcept C2779078216 @default.
• W2081799074 hasConcept C2780801004 @default.
• W2081799074 hasConcept C2780868878 @default.
• W2081799074 hasConcept C2781069245 @default.
• W2081799074 hasConcept C40767141 @default.
• W2081799074 hasConcept C55493867 @default.
• W2081799074 hasConcept C71924100 @default.
• W2081799074 hasConcept C86803240 @default.
• W2081799074 hasConcept C8891405 @default.
• W2081799074 hasConcept C89423630 @default.
• W2081799074 hasConceptScore W2081799074C104317684 @default.
• W2081799074 hasConceptScore W2081799074C123894998 @default.
• W2081799074 hasConceptScore W2081799074C142724271 @default.
• W2081799074 hasConceptScore W2081799074C159047783 @default.
• W2081799074 hasConceptScore W2081799074C167508917 @default.
• W2081799074 hasConceptScore W2081799074C203014093 @default.
• W2081799074 hasConceptScore W2081799074C205260736 @default.
• W2081799074 hasConceptScore W2081799074C2777975735 @default.
• W2081799074 hasConceptScore W2081799074C2779078216 @default.
• W2081799074 hasConceptScore W2081799074C2780801004 @default.
• W2081799074 hasConceptScore W2081799074C2780868878 @default.
• W2081799074 hasConceptScore W2081799074C2781069245 @default.
• W2081799074 hasConceptScore W2081799074C40767141 @default.
• W2081799074 hasConceptScore W2081799074C55493867 @default.
• W2081799074 hasConceptScore W2081799074C71924100 @default.
• W2081799074 hasConceptScore W2081799074C86803240 @default.
• W2081799074 hasConceptScore W2081799074C8891405 @default.
• W2081799074 hasConceptScore W2081799074C89423630 @default.
• W2081799074 hasIssue "12" @default.
• W2081799074 hasLocation W20817990741 @default.
• W2081799074 hasLocation W20817990742 @default.
• W2081799074 hasOpenAccess W2081799074 @default.

• next