FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081799650> ?p ?o ?g. }

• W2081799650 endingPage "6946" @default.
• W2081799650 startingPage "6938" @default.
• W2081799650 abstract "Luminescent lanthanide complexes (Tb3+, Eu3+, etc.) have excellent properties for biological applications, including extraordinarily long lifetimes and large Stokes shifts. However, there have been few reports of lanthanide-based functional probes, because of the difficulty in designing suitable complexes with a luminescent on/off switch. Here, we have synthesized a series of complexes which consist of three moieties: a lanthanide chelate, an antenna, and a luminescence off/on switch. The antenna is an aromatic ring which absorbs light and transmits its energy to the metal, and the switch is a benzene derivative with a different HOMO level. If the HOMO level is higher than a certain threshold, the complex emits no luminescence at all, which indicates that the lanthanide luminescence can be modulated by photoinduced electron transfer (PeT) from the switch to the sensitizer. This approach to control lanthanide luminescence makes possible the rational design of functional lanthanide complexes, in which the luminescence property is altered by a biological reaction. To exemplify the utility of our approach to the design of lanthanide complexes with a switch, we have developed a novel protease probe, which undergoes a significant change in luminescence intensity upon enzymatic cleavage of the substrate peptide. This probe, combined with time-resolved measurements, was confirmed in model experiments to be useful for the screening of inhibitors, as well as for clinical diagnosis." @default.
• W2081799650 created "2016-06-24" @default.
• W2081799650 creator A5004429556 @default.
• W2081799650 creator A5013915106 @default.
• W2081799650 creator A5022773533 @default.
• W2081799650 creator A5032400721 @default.
• W2081799650 creator A5035830409 @default.
• W2081799650 creator A5049104572 @default.
• W2081799650 creator A5062136657 @default.
• W2081799650 date "2006-05-01" @default.
• W2081799650 modified "2023-10-14" @default.
• W2081799650 title "Modulation of Luminescence Intensity of Lanthanide Complexes by Photoinduced Electron Transfer and Its Application to a Long-Lived Protease Probe" @default.
• W2081799650 cites W1600997361 @default.
• W2081799650 cites W1966497279 @default.
• W2081799650 cites W1968858321 @default.
• W2081799650 cites W1969564552 @default.
• W2081799650 cites W1970701724 @default.
• W2081799650 cites W1970803380 @default.
• W2081799650 cites W1973649612 @default.
• W2081799650 cites W1976581939 @default.
• W2081799650 cites W1977405695 @default.
• W2081799650 cites W1981571886 @default.
• W2081799650 cites W1982973867 @default.
• W2081799650 cites W1986625209 @default.
• W2081799650 cites W2010055809 @default.
• W2081799650 cites W2014905614 @default.
• W2081799650 cites W2018327543 @default.
• W2081799650 cites W2019108383 @default.
• W2081799650 cites W2022115343 @default.
• W2081799650 cites W2033503179 @default.
• W2081799650 cites W2034557800 @default.
• W2081799650 cites W2046062017 @default.
• W2081799650 cites W2048508921 @default.
• W2081799650 cites W2058150501 @default.
• W2081799650 cites W2059546764 @default.
• W2081799650 cites W2062253359 @default.
• W2081799650 cites W2066489771 @default.
• W2081799650 cites W2069662113 @default.
• W2081799650 cites W2070280773 @default.
• W2081799650 cites W2072522913 @default.
• W2081799650 cites W2076271825 @default.
• W2081799650 cites W2080453662 @default.
• W2081799650 cites W2083062424 @default.
• W2081799650 cites W2083191957 @default.
• W2081799650 cites W2085114962 @default.
• W2081799650 cites W2088385150 @default.
• W2081799650 cites W2090202623 @default.
• W2081799650 cites W2092485720 @default.
• W2081799650 cites W2094485763 @default.
• W2081799650 cites W2099021383 @default.
• W2081799650 cites W2111091421 @default.
• W2081799650 cites W2111361116 @default.
• W2081799650 cites W2114305848 @default.
• W2081799650 cites W2119823606 @default.
• W2081799650 cites W2121685173 @default.
• W2081799650 cites W2124639076 @default.
• W2081799650 cites W2126578481 @default.
• W2081799650 cites W2133616096 @default.
• W2081799650 cites W2141260882 @default.
• W2081799650 cites W2145773666 @default.
• W2081799650 cites W2146434490 @default.
• W2081799650 cites W2153282431 @default.
• W2081799650 cites W2153885285 @default.
• W2081799650 cites W2155645504 @default.
• W2081799650 cites W2312375107 @default.
• W2081799650 cites W2330386413 @default.
• W2081799650 cites W2473345418 @default.
• W2081799650 doi "https://doi.org/10.1021/ja060729t" @default.
• W2081799650 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16719474" @default.
• W2081799650 hasPublicationYear "2006" @default.
• W2081799650 type Work @default.
• W2081799650 sameAs 2081799650 @default.
• W2081799650 citedByCount "141" @default.
• W2081799650 countsByYear W20817996502012 @default.
• W2081799650 countsByYear W20817996502013 @default.
• W2081799650 countsByYear W20817996502014 @default.
• W2081799650 countsByYear W20817996502015 @default.
• W2081799650 countsByYear W20817996502016 @default.
• W2081799650 countsByYear W20817996502017 @default.
• W2081799650 countsByYear W20817996502018 @default.
• W2081799650 countsByYear W20817996502019 @default.
• W2081799650 countsByYear W20817996502020 @default.
• W2081799650 countsByYear W20817996502021 @default.
• W2081799650 countsByYear W20817996502022 @default.
• W2081799650 countsByYear W20817996502023 @default.
• W2081799650 crossrefType "journal-article" @default.
• W2081799650 hasAuthorship W2081799650A5004429556 @default.
• W2081799650 hasAuthorship W2081799650A5013915106 @default.
• W2081799650 hasAuthorship W2081799650A5022773533 @default.
• W2081799650 hasAuthorship W2081799650A5032400721 @default.
• W2081799650 hasAuthorship W2081799650A5035830409 @default.
• W2081799650 hasAuthorship W2081799650A5049104572 @default.
• W2081799650 hasAuthorship W2081799650A5062136657 @default.
• W2081799650 hasConcept C111368507 @default.
• W2081799650 hasConcept C123669783 @default.
• W2081799650 hasConcept C127313418 @default.
• W2081799650 hasConcept C145148216 @default.
• W2081799650 hasConcept C148869448 @default.

• next