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- W2081803634 abstract "Annals of the New York Academy of SciencesVolume 492, Issue 1 p. 71-87 General Anesthetic and Specific Effects of Ethanol on Acetylcholine Receptorsa KEITH W. MILLER, KEITH W. MILLER Departments of Anaesthesia and Pharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114Search for more papers by this authorLEONARD L. FIRESTONE AND, LEONARD L. FIRESTONE AND Departments of Anaesthesia and Pharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114Search for more papers by this authorSTUART A. FORMAN, STUART A. FORMAN Departments of Anaesthesia and Pharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114Search for more papers by this author KEITH W. MILLER, KEITH W. MILLER Departments of Anaesthesia and Pharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114Search for more papers by this authorLEONARD L. FIRESTONE AND, LEONARD L. FIRESTONE AND Departments of Anaesthesia and Pharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114Search for more papers by this authorSTUART A. FORMAN, STUART A. FORMAN Departments of Anaesthesia and Pharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114Search for more papers by this author First published: April 1987 https://doi.org/10.1111/j.1749-6632.1987.tb48656.xCitations: 26 a Supported by National Institute of General Medical Sciences Training Grant GM-07592 and Center Grant GM-15904 to the Harvard Anaesthesia Research Center and by the Department of Anesthesia, Massachusetts General Hospital. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Forman, S. A., A. S. Verkman, J. A. Dix & A. K. Solomon. 1985. n-Alkanols and halothane inhibit red cell anion transport and increase band 3 conformational change rate. Biochemistry 24: 4859– 4866. 2 Miller, K. W. 1985. The nature of the site of general anesthesia. Int. Rev. Neurobiol. 27: 1– 57. 3 Roth, S. H. 1979. Physical mechanisms of anesthesia. Annu. Rev. Pharmacol. Toxicol. 19: 159– 178. 4 Janoff, A. S. & K. W. Miller. 1982. A critical assessment of the lipid theories of general anaesthetic action. 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The solubility of hydrocarbon gases in lipid bilayers. Chem. Phys. Lipids 20: 229– 241. 11 Katz, Y. & J. M. Diamond. 1974. Thermodynamic constants for nonelectrolyte partition between dimyristoyl lecithin and water. J. Membr. Biol. 17: 101– 120. 12 Colley, C. M., S. M. Metcalfe, B. Turner, A. S. V. Burgen & J. C. Metcalfe. 1971. The binding of benzyl alcohol to erythrocyte membranes. Biochim. Biophys. Acta 233: 720– 729. 13 Jain, M. K. & N. M. Wu. 1977. Effect of small molecules on the dipalmitoyl lecithin liposomal bilayers: III. Phase transition in lipid bilayers. J. Membr. Biol. 34: 157– 201. 14 Rowe, E. S. 1983. Lipid chain length and temperature dependence of ethanol-phosphatidyl-choline interactions. Biochemistry 22: 3299– 3305. 15 Urban, B. W. 1985. Modifications of excitable membranes by volatile and gaseous anesthetics. In Effects of Anesthesia. B. G. Covino, H. A. Fozzard, K. Rehder & G. Strichartz, Eds. 13– 28. American Physiological Society. Bethesda , MD . 16 Haydon, J., J. R. Elliott, B. M. Hendry & B. W. Urban. 1986. The action of nonionic anesthetic substances on voltage-gated ion conductances in squid giant axons. In Molecular and Cellular Mechanisms of Anesthetics. S. H. Roth & K. W. Miller, Eds. 267– 277. Plenum Publishing Company. New York , NY . 17 Williams, R. J. P. 1979. The conformational properties of proteins in solution. Biol. Rev. 54: 389– 437. 18 Settle, W. 1973. Function of the myoglobin molecule as influenced by anesthetic molecules. In A Guide to Molecular Pharmacology and Toxicology. R. M. Featherstone, Ed. Part II: 477– 493. Marcel Dekker, Inc. New York , N.Y . 19 Tilton, R. F., Jr., I. D. Kuntz, Jr. & G. A. Petsko. 1984. Cavities in proteins: structure of a metmyoglobin-xenon complex solved to 1.9 Å. Biochemistry 23: 2849– 2857. 20 Franks, N. P. & W. R. Lieb. 1984. Do general anaesthetics act by competitive binding to specific receptors Nature 310: 599– 601. 21 Noda, M., H. Takahashi, T. Tanabe, M. Toyosato, S. Kikyotani, Y. Furutani, T. Hirose, H. Takashima, S. Inayama, T. Miyata & S. Numa. 1983. Structural homology of Torpedo californica acetylcholine receptor subunits. Nature 302: 528– 532. 22 Conti-Tronconi, B. M. & M. A. Raitery. 1982. The nicotinic cholinergic receptor: correlation of molecular structure with functional properties. Annu. Rev. Biochem. 51: 491– 530. 23 Changeux, J. -P., A. Devillers-Thiery & P. Chemouilli. 1984. Acetylcholine receptor: an allosteric protein. Science 225: 1335– 1345. 24 Fairclough, R. H., J. Finer-More, R. A. Love, D. Kristofferson, P. J. Desmeules & R. M. Stroud. 1983. Subunit organization and structure of an acetylcholine receptor. Cold Spring Harbor Symposium on Quant. Biol. 48: 9– 20. 25 Sackman, B., C. Methfessel, M. Mishina, T. Takahashi, T. Takai, M. Kurasaki, K. Fukuda & S. Numa. 1985. Role of acetylcholine receptor subunits in gating of the channel. Nature 318: 538– 543. 26 Fong, T. M. & M. G. McNamee. 1986. Correlation between acetylcholine receptor function and structural properties of membranes. Biochemistry 25: 830– 840. 27 Neubig, R. R., N. D. Boyd & J. B. Cohen. 1982. Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitization. Biochemistry 21: 3460– 3467. 28 Gage, P. W. & O. P. Hamill. 1981. Effects of anesthetics on ion channels in synapses. Int. Rev. Physiol. 25: 1– 45. 29 Bradley, R. J., R. Sterz & K. Peper. 1984. The effects of alcohols and diols at the nicotinic acetylcholine receptor of the neuromuscular junction. Brain Res. 295: 101– 112. 30 McLarnon, J. G., P. Pennefather & D. M. J. Quastel. 1986. Mechanism of nicotinic channel blockade by anesthetics. In Molecular and Cellular Mechanisms of Anesthetics. S. H. Roth & K. W. Miller, Eds. 155– 164. Plenum Publishing Company. New York , NY . 31 Gage, P. W., D. McKinnon & B. Robertson. 1986. The influence of anesthetics on postsynaptic ion channels. In Molecular and Cellular Mechanisms of Anesthetics. S. H. Roth & K. W. Miller, Eds. 139– 153. Plenum Publishing Company. New York , NY . 32 Boyd, N. D. & J. Cohen. 1984. Desensitization of membrane-bound Torpedo acetylcholine receptor by amine noncompetitive antagonists and aliphatic alcohols: studies of [3H]-acetylcholine binding and 22Na+ ion fluxes. Biochemistry 23: 4023– 4033. 33 Young, A. P. & D. S. Sigman. 1981. Allosteric effect of volatile anesthetics on the membrane-bound acetylcholine receptor. Mol. Pharmacol. 20: 498– 505. 34 El-Fakahany, E. F., E. R. Miller, M. A. Abbassy, A. T. Eldefrawi & M. E. Eldefrawi. 1983. Alcohol modulation of drug binding to the channel sites of the nicotinic acetylcholine receptor. J. Pharmacol. Exp. Ther. 224: 289– 296. 35 Braswell, L. M., K. W. Miller & J. F. Sauter. 1984. Pressure reversal of the action of octanol on postsynaptic membranes from Torpedo. Br. J. Pharmacol. 83: 305– 311. 36 Miller, K. W., L. M. Braswell, L. L. Firestone, B. A. Dodson & S. A. Forman. 1986. General anesthetics act both specifically and nonspecifically on acetylcholine receptors. In Molecular and Cellular Mechanisms of Anesthetics. S. H. Roth & K. W. Miller, Eds. 125– 137. Plenum Medical Book Company. New York , NY . 31 Firestone, L. L., J.-F. Sauter, L. M. Braswell & K. W. Miller. 1986. The actions of general anesthetics on acetylcholine receptor-rich membranes from Torpedo. Anesthesiology 64: 694– 702. 38 Hubbell, W. L. & H. M. McConnell. 1971. Molecular motion in spin-labeled phospholipids and membranes. J. Amer. Chem. Soc. 93: 314– 326. 39 Nelson, D. J. & F. Sachs. 1981. Ethanol decreases dissociation of agonist from nicotinic channels. Biophys. J. 33: 121a. 40 Meyer, H. H. 1901. Zur theorie der alkoholnarkose. Arch. Exp. Pathol. Pharmakol. 46: 338– 346. Citing Literature Volume492, Issue1Alcohol and the CellApril 1987Pages 71-87 ReferencesRelatedInformation" @default.
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