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• W2081806406 abstract "Several lines of evidence have suggested that protein tyrosine phosphatases , including CD45 and SHP-1, regulate macrophage activation . Macrophages from mice lacking SHP-1 (motheaten mice) are hyper-responsive to many stimuli, suggesting that SHP-1 may negatively regulate macrophage activation. Herein we report that the repressible/inducible over-expression of wild-type SHP-1 in a subclone of RAW 264.7 macrophages (RAW-TT10 cells) inhibited both TNF secretion and iNOS protein accumulation in response to stimulation with lipopolysaccharide (LPS) and recombinant murine interferon-gamma and led to diminished LPS-mediated tyrosine phosphorylation of vav1 . In contrast, expression of a truncated SHP-1 construct previously shown to interfere with endogenous SHP-1 function modestly augmented LPS-mediated TNF and iNOS production and did not inhibit vav1 tyrosine phosphorylation. Taken together, these data provide the first direct evidence that SHP-1 inhibits macrophage activation by LPS and suggest that this effect may be mediated in part by dephosphorylation of vav1 ." @default.
• W2081806406 created "2016-06-24" @default.
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• W2081806406 date "2006-04-01" @default.
• W2081806406 modified "2023-09-23" @default.
• W2081806406 title "SHP-1 inhibits LPS-mediated TNF and iNOS production in murine macrophages" @default.
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• W2081806406 doi "https://doi.org/10.1016/j.bbrc.2006.02.005" @default.
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