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- W2081811839 abstract "1. DPN-pyrophosphorylase has been found to be associated with a certain kind of nuclear ribosomes. Methods are described for the isolation of ribosomes possesing DPN-pyrophosphorylase activity from both rat liver and Krebs-2 tumor nuclei. 2. A method has been developed for the extraction and purification of DPN-pyrophosphorylase from rat liver nuclei. 3. The ability of nuclei, isolated from various tumor cells, to synthesize DPN from NMN and ATP was compared to that of rat liver nuclei. The rate of DPN synthesis by tumor nuclei was found to be about 15–20 per cent of that manifested by rat liver nuclei. 4. No evidence was found to support the assumption that the low DPN-pyrophosphorylase activity of tumor nuclei is due to inhibition of enzymatic activity by nuclear constituents." @default.
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- W2081811839 date "1964-04-01" @default.
- W2081811839 modified "2023-10-10" @default.
- W2081811839 title "Studies on nuclear ribosomes I. Association of DPN-pyrophosphorylase with nuclear ribosomes in normal and neoplastic tissues" @default.
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- W2081811839 doi "https://doi.org/10.1016/0014-4827(64)90372-6" @default.
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