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- W2081814095 abstract "Abstract Lithium fluxes were measured for bovine erythrocyte suspensions in normal Ringer at 37°. Apparent cell concentraion, mmole Li/ liter packed cells, increased rapidly with time until a maximum was attained, then decreased to a constant or equilibrium value. The correlation between apparent maximum cell uptake and effective external lithium concentration (external lithium concentration divided by hematocrit) was significant ( r = 0.966, P = ). The equilibrium cell concentration showed a correlation ( r = 0.842, P = ) with lithium gradient (ratio of internal and external lithium concentrations). Loss of lithium from cells followed first-order kinetic law, and the rate constant showed a correlation ( r = 0.959, P = ) with the initial lithium gradient. The effect of dipivaloylmethane (DPM) on lithium influx and efflux was studied. The chelating agent enhanced the rate of lithium removal from lithium-loaded cells. For lithium influx, the effect of chelating agent appears to be a semi-logarithmic function, flux = a log [ DPM ] ( r = 0.993, P = 0.05) , implications of these observations to the design of lithium control agents are considered." @default.
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- W2081814095 date "1973-03-01" @default.
- W2081814095 modified "2023-10-17" @default.
- W2081814095 title "Effect of selected β-diketones on lithium fluxes of bovine red blood cells" @default.
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- W2081814095 doi "https://doi.org/10.1016/0024-3205(73)90358-5" @default.
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