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• W2081843921 abstract "The β-globin gene cluster of the brown lemur, a prosimian, is very short and contains a single ϵ-, γ- and β-globin gene, with an additional β-related gene sequence between the γ- and β-globin genes. Brown lemur DNA was cloned into the bacteriophage vector λL47.1 and a recombinant was isolated which contained an 11 × 10 3 base insert including the β-globin gene and the additional putative β-globin pseudogene. The nucleotide sequence of this β-related gene was completely determined. A complete gene sequence was found, containing four frameshift mutations sufficient to establish its pseudogene status. The gene was interrupted by two intervening sequences with sizes and locations typical of mammalian β-related globin genes. The pseudogene sequence was compared in detail with human ϵ-, γ-, δ- and β-globin genes. The beginning of the pseudogene, from the 5′ flanking region to the second exon, was homologous to the corresponding regions of the human ϵ- and γ-globin genes. In contrast, the second intron, third exon and 3′ flanking region showed a remarkably close homology to the δ-globin, but not β-globin, gene of man. This suggests that the δ-globin gene is not the product of a recent gene duplication, but instead is present in most or all primates. This gene has been silenced on at least two separate occasions in primate evolution (in lemurs and in old world monkeys). In addition, the 5′ end of the lemur ψδ gene appears to have exchanged sequences with an ϵ- or γ-globin gene, and an analogous exchange with the β-globin gene seems to have occurred recently in the human δ-globin gene. The evolution and function of the δ-globin gene are discussed." @default.
• W2081843921 created "2016-06-24" @default.
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• W2081843921 date "1982-04-01" @default.
• W2081843921 modified "2023-09-29" @default.
• W2081843921 title "Isolation and sequence analysis of a hybrid δ-globin pseudogene from the brown lemur" @default.
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• W2081843921 doi "https://doi.org/10.1016/0022-2836(82)90262-5" @default.
• W2081843921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6214636" @default.
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