FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081845512> ?p ?o ?g. }

• W2081845512 endingPage "668" @default.
• W2081845512 startingPage "658" @default.
• W2081845512 abstract "Patients with schizophrenia often have anxiety and depression, and thus are treated with multiple psychotherapeutic medications. This practice of polypharmacy increases the possibility for drug–drug interactions. However, the pharmacological and behavioral mechanisms underlying drug–drug interactions in schizophrenia remain poorly understood. In the present study, we adopted a preclinical approach and examined a less known behavioral mechanism, drug–drug conditioning (DDC) between haloperidol (a typical antipsychotic) or olanzapine (atypical antipsychotic) and citalopram (a selective serotonin reuptake inhibitor). A rat two-way conditioned avoidance response paradigm was used to measure antipsychotic activity and determine how DDC may alter the antipsychotic efficacy in this model. Following acquisition of the avoidance response, rats were then randomly assigned to receive vehicle, citalopram (10.0 mg/kg, intraperitoneally), haloperidol (0.05 mg/kg, subcutaneously), olanzapine (1.0 mg/kg, subcutaneously), combined haloperidol with citalopram, or combined olanzapine with citalopram treatment for seven avoidance test sessions. In comparison with antipsychotic treatment alone, combined treatment with citalopram potentiated the antiavoidance effect of olanzapine or haloperidol (to a lesser extent) during the seven drug-test sessions. In addition, repeated pairing of citalopram with haloperidol or olanzapine caused citalopram to show a newly acquired avoidance-disruptive effect. This effect was context specific because citalopram paired with haloperidol or olanzapine outside the avoidance testing context (i.e. home cages) did not show such an effect. These findings indicate that concurrent antidepressant and antipsychotic treatments may engender a DDC process that follows the general Pavlovian associative conditioning principles. They also indicate that adjunctive citalopram treatment may enhance the antipsychotic efficacy of haloperidol and olanzapine in the treatment of schizophrenia." @default.
• W2081845512 created "2016-06-24" @default.
• W2081845512 creator A5021384155 @default.
• W2081845512 creator A5029802714 @default.
• W2081845512 date "2012-10-01" @default.
• W2081845512 modified "2023-09-27" @default.
• W2081845512 title "Drug–drug conditioning between citalopram and haloperidol or olanzapine in a conditioned avoidance response model" @default.
• W2081845512 cites W131563628 @default.
• W2081845512 cites W181091104 @default.
• W2081845512 cites W1968646118 @default.
• W2081845512 cites W1970209827 @default.
• W2081845512 cites W1975594581 @default.
• W2081845512 cites W1976894518 @default.
• W2081845512 cites W1977397003 @default.
• W2081845512 cites W1982937133 @default.
• W2081845512 cites W1984823171 @default.
• W2081845512 cites W1985422218 @default.
• W2081845512 cites W1989004497 @default.
• W2081845512 cites W1989623306 @default.
• W2081845512 cites W1992286080 @default.
• W2081845512 cites W1997895915 @default.
• W2081845512 cites W1999898236 @default.
• W2081845512 cites W2005169355 @default.
• W2081845512 cites W2005310936 @default.
• W2081845512 cites W2005736815 @default.
• W2081845512 cites W2010928240 @default.
• W2081845512 cites W2018742347 @default.
• W2081845512 cites W2019679310 @default.
• W2081845512 cites W2030445167 @default.
• W2081845512 cites W2035955419 @default.
• W2081845512 cites W2052088109 @default.
• W2081845512 cites W2055126281 @default.
• W2081845512 cites W2055684699 @default.
• W2081845512 cites W2059441616 @default.
• W2081845512 cites W2061363715 @default.
• W2081845512 cites W2063763742 @default.
• W2081845512 cites W2066616619 @default.
• W2081845512 cites W2071890704 @default.
• W2081845512 cites W2073685549 @default.
• W2081845512 cites W2077516336 @default.
• W2081845512 cites W2079857284 @default.
• W2081845512 cites W2083188821 @default.
• W2081845512 cites W2088626092 @default.
• W2081845512 cites W2093286170 @default.
• W2081845512 cites W2099028239 @default.
• W2081845512 cites W2110080420 @default.
• W2081845512 cites W2135194059 @default.
• W2081845512 cites W2142151511 @default.
• W2081845512 cites W2144168709 @default.
• W2081845512 cites W2159992706 @default.
• W2081845512 cites W2164875368 @default.
• W2081845512 cites W2165843693 @default.
• W2081845512 cites W2167050490 @default.
• W2081845512 cites W2169918425 @default.
• W2081845512 cites W1954801359 @default.
• W2081845512 cites W2092000908 @default.
• W2081845512 cites W2401248499 @default.
• W2081845512 doi "https://doi.org/10.1097/fbp.0b013e328358590d" @default.
• W2081845512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4755296" @default.
• W2081845512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22903071" @default.
• W2081845512 hasPublicationYear "2012" @default.
• W2081845512 type Work @default.
• W2081845512 sameAs 2081845512 @default.
• W2081845512 citedByCount "13" @default.
• W2081845512 countsByYear W20818455122012 @default.
• W2081845512 countsByYear W20818455122013 @default.
• W2081845512 countsByYear W20818455122014 @default.
• W2081845512 countsByYear W20818455122015 @default.
• W2081845512 countsByYear W20818455122016 @default.
• W2081845512 countsByYear W20818455122017 @default.
• W2081845512 countsByYear W20818455122018 @default.
• W2081845512 countsByYear W20818455122022 @default.
• W2081845512 countsByYear W20818455122023 @default.
• W2081845512 crossrefType "journal-article" @default.
• W2081845512 hasAuthorship W2081845512A5021384155 @default.
• W2081845512 hasAuthorship W2081845512A5029802714 @default.
• W2081845512 hasBestOaLocation W20818455122 @default.
• W2081845512 hasConcept C118552586 @default.
• W2081845512 hasConcept C151730666 @default.
• W2081845512 hasConcept C15744967 @default.
• W2081845512 hasConcept C169760540 @default.
• W2081845512 hasConcept C2775870346 @default.
• W2081845512 hasConcept C2776412080 @default.
• W2081845512 hasConcept C2776619155 @default.
• W2081845512 hasConcept C2776921671 @default.
• W2081845512 hasConcept C2777490545 @default.
• W2081845512 hasConcept C2779177272 @default.
• W2081845512 hasConcept C2779343474 @default.
• W2081845512 hasConcept C2780092697 @default.
• W2081845512 hasConcept C2780494398 @default.
• W2081845512 hasConcept C2780864610 @default.
• W2081845512 hasConcept C2780948584 @default.
• W2081845512 hasConcept C513476851 @default.
• W2081845512 hasConcept C558461103 @default.
• W2081845512 hasConcept C71924100 @default.
• W2081845512 hasConcept C86803240 @default.
• W2081845512 hasConcept C98274493 @default.
• W2081845512 hasConceptScore W2081845512C118552586 @default.

• next