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- W2081857438 abstract "The effect of thymidine (dT) and 5-fluorodeoxyuridine (FdU) on the frequency of sister-chromatid exchanges (SCEs) was examined in root-tip cells of Allium cepa. dT was unable to induce SCEs at all the concentrations tested. In contrast, FdU was efficient in the induction of SCEs. A nearly 3-fold increase in the frequency of SCEs was obtained with 5 · 10−7 M FdU when it was present only for the first 5-bromodeoxyuridine (BrdU) for 2 consecutive cell cycles. Also, when FdU was present only for the first round of replication, the rate of SCEs in M2 chromosomes was notably higher than when it was given only during the second replication round. By analyzing M3 chromosomes treated during the second replication round with FdU the results also supported the hypothesis that the majority of the FdU-induced SCEs arise as a consequence of a higher rate of BrdU incorporation, and that most of them are formed when BrdU-containing strands are used as template for DNA synthesis." @default.
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- W2081857438 date "1985-08-01" @default.
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- W2081857438 title "Induction of sister-chromatid exchanges (SCEs) by 5-fluorodeoxyuridine The role of 5-bromodeoxyuridine incorporated into parental DNA" @default.
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- W2081857438 doi "https://doi.org/10.1016/0027-5107(85)90185-x" @default.
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