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• W2081870982 abstract "Essential fatty acid (EFA) deficiency is an important tool in probing the role of arachidonic acid (20:4(n−6)) in pathophysiologic processes, but requires stringent and prolonged deprivation of (n−6) fatty acids. The present study investigated whether induction of the Δ9 desaturase, which is responsible for the synthesis of oleate, the precursor of 20:3(n−9) which uniquely accumulates in the deficiency state, might serve to accelerate the biochemical and biological effects of EFA deficiency. By alternately fasting and feeding animals a fat-free diet, it was possible to induce markedly the Δ9 desaturase selectively in liver. This dietary manipulation in consequence led to dramatic and rapid changes in hepatic phospholipid fatty acid composition. Within 2 weeks, 20:3(n−9) to 20:4(n−6) ratios in liver phospholipids were several fold greater than those seen in animals fed a fat-free diet alone. These changes, however, contrasted with those seen in the serum and other tissues. The mol% of 20:3(n−9) in serum was not increased by Δ9 desaturase induction and the 20:3(n−9) to 20:4(n−6) ratio was only modestly increased. The effects of Δ9 desaturase induction were even more attenuated in tissues other than the liver. Desaturase induction led to a doubling in the 20:3(n−9) to 20:4(n−6) ratio in phosphatidylcholine in renal cortex and heart, although the ratio in the other phospholipids was unaffected. The 20:3(n−9) to 20:4(n−6) ratio in peritoneal macrophage phospholipids was unaffected by desaturase induction. Thus, Δ9 desaturase induction greatly augments the synthesis of (n−9) fatty acids within the liver and leads to the rapid and substantial accumulation of the abnormal fatty acid, 20:3(n−9). This markedly augmented synthesis of hepatic 20:3(n−9), however, is not reflected in increased plasma levels of 20:3(n−9), and thus the effects of Δ9 desaturase induction are attenuated in tissues other than the liver. These data underscore the notable ability of the liver to maintain polyunsaturated fatty acid homeostasis." @default.
• W2081870982 created "2016-06-24" @default.
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• W2081870982 date "1990-05-01" @default.
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• W2081870982 title "Accelerated essential fatty acid deficiency by Δ9 desaturase induction: dissociation between the effects on liver and other tissues" @default.
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• W2081870982 doi "https://doi.org/10.1016/0005-2760(90)90212-g" @default.
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