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- W2081873778 abstract "Values for the signal intensity (SI) of plasma samples spiked with different concentrations (0.005–25 mmol/L) of various paramagnetic agents (gadopentetate dimeglumine [Magnevist; Schering AG, Berlin, Germany]; gadoxetic acid [Eovist; Schering AG]; Gadomer-17 [Schering AG]; gadobenate dimeglumine [MultiHance; Bracco, Milan, Italy]; MS-325 [EPIX Medical, Cambridge, Mass); and the ultrasmall superparamagnetic iron oxide [USPIO], SH U 555C [Schering AG]) were measured at 1.5 T (Allegra; Siemens AG, Erlangen, Germany). A three-dimensional (3D) MRA sequence (4.7/1.89 [repetition time msec/echo time msec], 25° flip angle) was used. The SI values of the maximum intensity projections (MIP) were measured, and the apparent T1 and T2* relaxivities were calculated from the SI-versus-concentration curves using the known dependence of the SI from sequence parameters and relaxation times (1). MRA studies using a superconducting MR imager (Allegra; Siemens AG) were performed in rabbits after intravenous injection of two dose regimens. The contrast agents were injected after starting the imaging sequence to achieve optimum bolus concentrations during the k space of the sequence. Additional images were taken at 3, 10, and 30 minutes after dosing. A dose of 0.2 mmol/kg was used for all agents to allow a comparison of the various agents with the currently performed practice with extracellular gadolinium chelates (eg, Magnevist). A second dose was adjusted to the calculated T1 relaxivity of Magnevist in plasma." @default.
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- W2081873778 date "2002-01-01" @default.
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- W2081873778 title "Comparative Studies on the Efficacy of MRI Contrast Agents in MRA" @default.
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- W2081873778 doi "https://doi.org/10.1016/s1076-6332(03)80419-1" @default.
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