Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081891332> ?p ?o ?g. }
- W2081891332 endingPage "320" @default.
- W2081891332 startingPage "313" @default.
- W2081891332 abstract "In clinical practice, the analgesic effects of epidurally administered local anesthetics on chronic pain sometimes outlast the duration of drug action expected from their pharmacokinetics. To investigate the underlying mechanisms of this prolonged effect, we examined the effects of ropivacaine, a local anesthetic, on pain-related behavior in a rat model of neuropathic pain. We also analyzed changes in the expression of nerve growth factor (NGF), which is involved in plasticity of the nociceptive circuit after nerve injury.In a rat model of neuropathic pain produced by chronic constrictive injury (CCI) of the sciatic nerve, thermal hyperalgesia, and mechanical allodynia were observed from Day 3 after surgery. Ropivacaine or saline was administered through an epidural catheter once a day, every day, and from Days 7-13 after the CCI operation. NGF content was measured in the L4 dorsal root ganglion, the hindpaw skin, the L4/5 dorsal spinal cord, and the sciatic nerve, using enzyme immunoassay.The latency to withdrawal from thermal stimuli on the ipsilateral paw pads of CCI rats was significantly increased 4 days after the beginning of ropivacaine treatment, and thermal hyperalgesia was almost fully relieved. Similarly, mechanical allodynia was partially reduced after ropivacaine treatment. NGF content was increased in the L4 dorsal root ganglion on the ipsilateral, but not the contralateral, side, in CCI rats treated with ropivacaine.Repetitive administration of ropivacaine into the epidural space in CCI rats exerts an analgesic effect, possibly by inducing a plastic change in the nociceptive circuit." @default.
- W2081891332 created "2016-06-24" @default.
- W2081891332 creator A5007404554 @default.
- W2081891332 creator A5012235660 @default.
- W2081891332 creator A5016550043 @default.
- W2081891332 creator A5041892610 @default.
- W2081891332 creator A5086525882 @default.
- W2081891332 date "2008-01-01" @default.
- W2081891332 modified "2023-10-02" @default.
- W2081891332 title "The Prolonged Analgesic Effect of Epidural Ropivacaine in a Rat Model of Neuropathic Pain" @default.
- W2081891332 cites W1527531631 @default.
- W2081891332 cites W1912819003 @default.
- W2081891332 cites W1967377904 @default.
- W2081891332 cites W1979246434 @default.
- W2081891332 cites W1980557428 @default.
- W2081891332 cites W1983041694 @default.
- W2081891332 cites W1984498889 @default.
- W2081891332 cites W1985713820 @default.
- W2081891332 cites W1988059170 @default.
- W2081891332 cites W1996901528 @default.
- W2081891332 cites W1998453569 @default.
- W2081891332 cites W2003404396 @default.
- W2081891332 cites W2004832503 @default.
- W2081891332 cites W2007932041 @default.
- W2081891332 cites W2010505622 @default.
- W2081891332 cites W2017900900 @default.
- W2081891332 cites W2019579305 @default.
- W2081891332 cites W2030353006 @default.
- W2081891332 cites W2033552617 @default.
- W2081891332 cites W2035755233 @default.
- W2081891332 cites W2038025722 @default.
- W2081891332 cites W2038382746 @default.
- W2081891332 cites W2044488313 @default.
- W2081891332 cites W2044708038 @default.
- W2081891332 cites W2047794539 @default.
- W2081891332 cites W2048028185 @default.
- W2081891332 cites W2048869899 @default.
- W2081891332 cites W2058020736 @default.
- W2081891332 cites W2059524959 @default.
- W2081891332 cites W2063662390 @default.
- W2081891332 cites W2064985934 @default.
- W2081891332 cites W2069817524 @default.
- W2081891332 cites W2090702553 @default.
- W2081891332 cites W2105939522 @default.
- W2081891332 cites W2110659645 @default.
- W2081891332 cites W2113160492 @default.
- W2081891332 cites W2123484875 @default.
- W2081891332 cites W2133316133 @default.
- W2081891332 cites W2159027399 @default.
- W2081891332 cites W2160779124 @default.
- W2081891332 cites W4237669811 @default.
- W2081891332 cites W4244120396 @default.
- W2081891332 cites W4248263001 @default.
- W2081891332 doi "https://doi.org/10.1213/01.ane.0000296460.91012.51" @default.
- W2081891332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18165597" @default.
- W2081891332 hasPublicationYear "2008" @default.
- W2081891332 type Work @default.
- W2081891332 sameAs 2081891332 @default.
- W2081891332 citedByCount "64" @default.
- W2081891332 countsByYear W20818913322012 @default.
- W2081891332 countsByYear W20818913322013 @default.
- W2081891332 countsByYear W20818913322014 @default.
- W2081891332 countsByYear W20818913322015 @default.
- W2081891332 countsByYear W20818913322016 @default.
- W2081891332 countsByYear W20818913322018 @default.
- W2081891332 countsByYear W20818913322020 @default.
- W2081891332 countsByYear W20818913322021 @default.
- W2081891332 countsByYear W20818913322022 @default.
- W2081891332 crossrefType "journal-article" @default.
- W2081891332 hasAuthorship W2081891332A5007404554 @default.
- W2081891332 hasAuthorship W2081891332A5012235660 @default.
- W2081891332 hasAuthorship W2081891332A5016550043 @default.
- W2081891332 hasAuthorship W2081891332A5041892610 @default.
- W2081891332 hasAuthorship W2081891332A5086525882 @default.
- W2081891332 hasBestOaLocation W20818913321 @default.
- W2081891332 hasConcept C118552586 @default.
- W2081891332 hasConcept C126322002 @default.
- W2081891332 hasConcept C15490471 @default.
- W2081891332 hasConcept C170493617 @default.
- W2081891332 hasConcept C2775991916 @default.
- W2081891332 hasConcept C2776281502 @default.
- W2081891332 hasConcept C2777107010 @default.
- W2081891332 hasConcept C2777397205 @default.
- W2081891332 hasConcept C2777657843 @default.
- W2081891332 hasConcept C2777883359 @default.
- W2081891332 hasConcept C2778994108 @default.
- W2081891332 hasConcept C2779245659 @default.
- W2081891332 hasConcept C2780269707 @default.
- W2081891332 hasConcept C2780775167 @default.
- W2081891332 hasConcept C2780820201 @default.
- W2081891332 hasConcept C2781149210 @default.
- W2081891332 hasConcept C42219234 @default.
- W2081891332 hasConcept C71924100 @default.
- W2081891332 hasConceptScore W2081891332C118552586 @default.
- W2081891332 hasConceptScore W2081891332C126322002 @default.
- W2081891332 hasConceptScore W2081891332C15490471 @default.
- W2081891332 hasConceptScore W2081891332C170493617 @default.
- W2081891332 hasConceptScore W2081891332C2775991916 @default.