Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081892038> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2081892038 endingPage "981" @default.
- W2081892038 startingPage "969" @default.
- W2081892038 abstract "We studied the effects of long-acting thyroid stimulator [LATS] and two unrelated compounds reported to be prostaglandin antagonists, 7-oxa-13-prostynoic acid [PY1] and polyphloretin phosphate [PPP] on adenyl cyclase activity in isolated bovine thyroid cells [ITC]. LATS-IgG stimulated ITC adenyl cyclase in a dose-related manner; the time-course of LATS-induced cyclase activation was comparable to that observed with thyrotropin [TSH] [onset at 5 min, maximal at 7.5 to 10 min]. PY1, 5 μg/ml [≌ 1.4 × 10−5M] and PPP, 5 μg/ml [≌ 3.3 × 10−8M], significantly inhibited the stimulatory effects of prostaglandin E2, TSH and LATS on ITC adenyl cyclase but did not modify basal cyclase activity. PPP, 0.5 mg, inhibited the effects of both TSH and LATS on mouse thyroid radioiodine release in vivo in an apparently competitive manner but did not modify dibutyryl cyclic AMP effects thereon. These studies suggest that activation of a prostaglandin receptor site may be an early step in the action of both LATS and TSH on thyroid." @default.
- W2081892038 created "2016-06-24" @default.
- W2081892038 creator A5077010171 @default.
- W2081892038 creator A5083132734 @default.
- W2081892038 date "1971-09-01" @default.
- W2081892038 modified "2023-09-26" @default.
- W2081892038 title "Effects of long-acting thyroid stimulator and prostaglandin antagonists on adenyl cyclase activity in isolated bovine thyroid cells" @default.
- W2081892038 cites W1979225743 @default.
- W2081892038 cites W1987310111 @default.
- W2081892038 cites W1994361909 @default.
- W2081892038 cites W2001090234 @default.
- W2081892038 cites W2001506022 @default.
- W2081892038 cites W2005886705 @default.
- W2081892038 cites W2009572080 @default.
- W2081892038 cites W2010984197 @default.
- W2081892038 cites W2015089855 @default.
- W2081892038 cites W2026912546 @default.
- W2081892038 cites W2044866113 @default.
- W2081892038 cites W2049785411 @default.
- W2081892038 cites W2050132042 @default.
- W2081892038 cites W2064705842 @default.
- W2081892038 cites W2069937753 @default.
- W2081892038 cites W2070454820 @default.
- W2081892038 cites W2079998396 @default.
- W2081892038 cites W2086625197 @default.
- W2081892038 cites W2092172723 @default.
- W2081892038 cites W2092459425 @default.
- W2081892038 cites W2149975410 @default.
- W2081892038 cites W2167107755 @default.
- W2081892038 cites W2468206562 @default.
- W2081892038 cites W4246724958 @default.
- W2081892038 doi "https://doi.org/10.1016/0024-3205(71)90100-7" @default.
- W2081892038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4328135" @default.
- W2081892038 hasPublicationYear "1971" @default.
- W2081892038 type Work @default.
- W2081892038 sameAs 2081892038 @default.
- W2081892038 citedByCount "24" @default.
- W2081892038 crossrefType "journal-article" @default.
- W2081892038 hasAuthorship W2081892038A5077010171 @default.
- W2081892038 hasAuthorship W2081892038A5083132734 @default.
- W2081892038 hasConcept C126322002 @default.
- W2081892038 hasConcept C134018914 @default.
- W2081892038 hasConcept C150903083 @default.
- W2081892038 hasConcept C170493617 @default.
- W2081892038 hasConcept C185592680 @default.
- W2081892038 hasConcept C207001950 @default.
- W2081892038 hasConcept C2778024521 @default.
- W2081892038 hasConcept C2779306644 @default.
- W2081892038 hasConcept C2780069284 @default.
- W2081892038 hasConcept C2780664492 @default.
- W2081892038 hasConcept C2781216419 @default.
- W2081892038 hasConcept C526584372 @default.
- W2081892038 hasConcept C71924100 @default.
- W2081892038 hasConcept C86803240 @default.
- W2081892038 hasConceptScore W2081892038C126322002 @default.
- W2081892038 hasConceptScore W2081892038C134018914 @default.
- W2081892038 hasConceptScore W2081892038C150903083 @default.
- W2081892038 hasConceptScore W2081892038C170493617 @default.
- W2081892038 hasConceptScore W2081892038C185592680 @default.
- W2081892038 hasConceptScore W2081892038C207001950 @default.
- W2081892038 hasConceptScore W2081892038C2778024521 @default.
- W2081892038 hasConceptScore W2081892038C2779306644 @default.
- W2081892038 hasConceptScore W2081892038C2780069284 @default.
- W2081892038 hasConceptScore W2081892038C2780664492 @default.
- W2081892038 hasConceptScore W2081892038C2781216419 @default.
- W2081892038 hasConceptScore W2081892038C526584372 @default.
- W2081892038 hasConceptScore W2081892038C71924100 @default.
- W2081892038 hasConceptScore W2081892038C86803240 @default.
- W2081892038 hasIssue "17" @default.
- W2081892038 hasLocation W20818920381 @default.
- W2081892038 hasLocation W20818920382 @default.
- W2081892038 hasOpenAccess W2081892038 @default.
- W2081892038 hasPrimaryLocation W20818920381 @default.
- W2081892038 hasRelatedWork W1979660518 @default.
- W2081892038 hasRelatedWork W1981780460 @default.
- W2081892038 hasRelatedWork W1985938011 @default.
- W2081892038 hasRelatedWork W2000995372 @default.
- W2081892038 hasRelatedWork W2006844127 @default.
- W2081892038 hasRelatedWork W2020688170 @default.
- W2081892038 hasRelatedWork W2026822609 @default.
- W2081892038 hasRelatedWork W2159228864 @default.
- W2081892038 hasRelatedWork W2169263215 @default.
- W2081892038 hasRelatedWork W2414656419 @default.
- W2081892038 hasVolume "10" @default.
- W2081892038 isParatext "false" @default.
- W2081892038 isRetracted "false" @default.
- W2081892038 magId "2081892038" @default.
- W2081892038 workType "article" @default.