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- W2081897462 abstract "The templates required for inducing posttranscriptional gene silencing (PTGS) effects have been investigated in human prostate cancer LNCaP cells. Transfection of a mRNA-cDNA hybrid construct was found to result in a relatively long-term interference of specific gene expression. Androgen-stimulated expression of bcl-2 has been reported to increase the tumorigenic and metastatic potentials of human prostate cancer LNCaP cells, as well as their resistance to many apoptotic stimuli. The addition of bcl-2 antisense oligonucleotides, however, restored apoptosis. Our studies demonstrate gene silencing effects of the mRNA-cDNA transfection that is similar to those of PTGS/RNAi in this in vitro prostate cancer cell model. A potential RNA-directed RNA polymerase activity was also detected which is alpha-amanitin-sensitive. These findings indicate that a novel gene silencing system may exist in mammalian cells." @default.
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- W2081897462 date "2001-03-01" @default.
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- W2081897462 title "A Novel mRNA–cDNA Interference Phenomenon for Silencing bcl-2 Expression in Human LNCaP Cells" @default.
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- W2081897462 doi "https://doi.org/10.1006/bbrc.2001.4412" @default.
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