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• W2081904841 abstract "This multicenter, open‐label study evaluated the effects of multiple doses of peginterferon alfa‐2b on the steady‐state pharmacokinetics of methadone in 20 adults with hepatitis C virus infection who were enrolled in a methadone maintenance program. All subjects received peginterferon alfa‐2b 1.5 μg/kg/wk for 4 weeks and maintained their normal methadone regimen. Serial blood samples were collected immediately before the first and after the fourth peginterferon alfa‐2b dose (day 23). At day 23, exposure to the active methadone R‐enantiomer increased by approximately 15% following administration of peginterferon alfa‐2b, with 90% confidence intervals just outside the bioequivalence criteria (range, 80%–125%). Similar increases in exposure (C max , AUC 0–24 , and AUC last ) were observed with S‐methadone and total methadone. Peginterferon alfa‐2b was well tolerated. Peginterferon alfa‐2b is associated with minor increases in exposure to methadone in individuals with hepatitis C virus infection; however, these increases are unlikely to be clinically meaningful and are not associated with any safety concerns." @default.
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• W2081904841 date "2007-05-01" @default.
• W2081904841 modified "2023-10-13" @default.
• W2081904841 title "The Effect of Multiple Doses of Peginterferon alfa-2b on the Steady-State Pharmacokinetics of Methadone in Patients With Chronic Hepatitis C Undergoing Methadone Maintenance Therapy" @default.
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• W2081904841 doi "https://doi.org/10.1177/0091270007299760" @default.
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