FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081906045> ?p ?o ?g. }

• W2081906045 endingPage "102" @default.
• W2081906045 startingPage "97" @default.
• W2081906045 abstract "Human neutrophils, plated in fibronectin-coated wells and stimulated with N-formyl-methionylleucyl-phenylalanine (fMLP), were found to undergo a massive and prolonged respiratory burst, as measured by monitoring superoxide production. The beta 2-agonist salmeterol inhibited the respiratory burst in a dose-dependent manner. In contrast, salbutamol was ineffective. Moreover, the neutrophil respiratory burst was partially suppressed by prostaglandin E2 (PGE2) and the phosphodiesterase type IV (PDE-IV) inhibitor RO 20-1724. When salmeterol was used in combination with PGE2 or RO 20-1724, additive inhibitory effects were observed. The inhibitory activity of salmeterol was not reversed in the presence of the beta-blocker propranolol, and did not correlate with its ability of increasing cyclic AMP (cAMP) levels. Finally, the compounds used did not affect neutrophil adherence to fibronectin-coated wells. The results suggest that salmeterol is capable of down-regulating the neutrophil oxidative response to fMLP, also of co-operating with PGE2 and PDE-IV inhibitor RO 20-1724 in a manner not related to its beta 2-receptor binding activity. In other words, salmeterol displays neutrophil-directed effects, susceptible to be amplified by natural mediators such as PGE2 or PDE-IV inhibitors, consistent with possible anti-inflammatory properties of the drug." @default.
• W2081906045 created "2016-06-24" @default.
• W2081906045 creator A5042094771 @default.
• W2081906045 creator A5045073940 @default.
• W2081906045 creator A5055297433 @default.
• W2081906045 creator A5061225153 @default.
• W2081906045 date "1996-10-01" @default.
• W2081906045 modified "2023-10-18" @default.
• W2081906045 title "Inhibitory effect of salmeterol on the respiratory burst of adherent human neutrophils" @default.
• W2081906045 cites W1255418 @default.
• W2081906045 cites W1502898912 @default.
• W2081906045 cites W1508470956 @default.
• W2081906045 cites W1555068638 @default.
• W2081906045 cites W1557673784 @default.
• W2081906045 cites W1591062957 @default.
• W2081906045 cites W1858326923 @default.
• W2081906045 cites W1968133040 @default.
• W2081906045 cites W2000017812 @default.
• W2081906045 cites W2005106478 @default.
• W2081906045 cites W2008081488 @default.
• W2081906045 cites W2013851053 @default.
• W2081906045 cites W2026267319 @default.
• W2081906045 cites W2026965224 @default.
• W2081906045 cites W2033788890 @default.
• W2081906045 cites W2041595076 @default.
• W2081906045 cites W2050995757 @default.
• W2081906045 cites W2070999103 @default.
• W2081906045 cites W2072019471 @default.
• W2081906045 cites W2085152092 @default.
• W2081906045 cites W2112260905 @default.
• W2081906045 cites W2118687030 @default.
• W2081906045 cites W2121721745 @default.
• W2081906045 cites W2137356321 @default.
• W2081906045 cites W2147743799 @default.
• W2081906045 cites W2157952919 @default.
• W2081906045 cites W2164508592 @default.
• W2081906045 cites W2415192806 @default.
• W2081906045 cites W2441528172 @default.
• W2081906045 cites W2072796605 @default.
• W2081906045 cites W2122138539 @default.
• W2081906045 doi "https://doi.org/10.1046/j.1365-2249.1996.d01-804.x" @default.
• W2081906045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2200548" @default.
• W2081906045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8870705" @default.
• W2081906045 hasPublicationYear "1996" @default.
• W2081906045 type Work @default.
• W2081906045 sameAs 2081906045 @default.
• W2081906045 citedByCount "37" @default.
• W2081906045 countsByYear W20819060452012 @default.
• W2081906045 countsByYear W20819060452015 @default.
• W2081906045 countsByYear W20819060452016 @default.
• W2081906045 crossrefType "journal-article" @default.
• W2081906045 hasAuthorship W2081906045A5042094771 @default.
• W2081906045 hasAuthorship W2081906045A5045073940 @default.
• W2081906045 hasAuthorship W2081906045A5055297433 @default.
• W2081906045 hasAuthorship W2081906045A5061225153 @default.
• W2081906045 hasBestOaLocation W20819060452 @default.
• W2081906045 hasConcept C126322002 @default.
• W2081906045 hasConcept C134018914 @default.
• W2081906045 hasConcept C185592680 @default.
• W2081906045 hasConcept C198677920 @default.
• W2081906045 hasConcept C203014093 @default.
• W2081906045 hasConcept C2776042228 @default.
• W2081906045 hasConcept C2776719499 @default.
• W2081906045 hasConcept C2776914184 @default.
• W2081906045 hasConcept C2777394947 @default.
• W2081906045 hasConcept C2778151854 @default.
• W2081906045 hasConcept C71924100 @default.
• W2081906045 hasConcept C86803240 @default.
• W2081906045 hasConcept C98274493 @default.
• W2081906045 hasConcept C99971728 @default.
• W2081906045 hasConceptScore W2081906045C126322002 @default.
• W2081906045 hasConceptScore W2081906045C134018914 @default.
• W2081906045 hasConceptScore W2081906045C185592680 @default.
• W2081906045 hasConceptScore W2081906045C198677920 @default.
• W2081906045 hasConceptScore W2081906045C203014093 @default.
• W2081906045 hasConceptScore W2081906045C2776042228 @default.
• W2081906045 hasConceptScore W2081906045C2776719499 @default.
• W2081906045 hasConceptScore W2081906045C2776914184 @default.
• W2081906045 hasConceptScore W2081906045C2777394947 @default.
• W2081906045 hasConceptScore W2081906045C2778151854 @default.
• W2081906045 hasConceptScore W2081906045C71924100 @default.
• W2081906045 hasConceptScore W2081906045C86803240 @default.
• W2081906045 hasConceptScore W2081906045C98274493 @default.
• W2081906045 hasConceptScore W2081906045C99971728 @default.
• W2081906045 hasIssue "1" @default.
• W2081906045 hasLocation W20819060451 @default.
• W2081906045 hasLocation W20819060452 @default.
• W2081906045 hasLocation W20819060453 @default.
• W2081906045 hasOpenAccess W2081906045 @default.
• W2081906045 hasPrimaryLocation W20819060451 @default.
• W2081906045 hasRelatedWork W1979676541 @default.
• W2081906045 hasRelatedWork W1984518302 @default.
• W2081906045 hasRelatedWork W1988623063 @default.
• W2081906045 hasRelatedWork W1994112692 @default.
• W2081906045 hasRelatedWork W2011602913 @default.
• W2081906045 hasRelatedWork W2068508192 @default.
• W2081906045 hasRelatedWork W2081906045 @default.
• W2081906045 hasRelatedWork W2091022983 @default.

• next