FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081906798> ?p ?o ?g. }

• W2081906798 endingPage "3249" @default.
• W2081906798 startingPage "3244" @default.
• W2081906798 abstract "Despite the fact that important genetic diseases are caused by mutant mitochondrial ribosomes, the molecular mechanisms by which such ribosomes result in a clinical phenotype remain largely unknown. The absence of experimental models for mitochondrial diseases has also prevented the rational search for therapeutic interventions. Here, we report on the construction of bacterial hybrid ribosomes that contain various versions of the mitochondrial decoding region of ribosomal RNA. We show that the pathogenic mutations A1555G and C1494T decrease the accuracy of translation and render the ribosomal decoding site hypersusceptible to aminoglycoside antibiotics. This finding suggests misreading of the genetic code as an important molecular mechanism in disease pathogenesis." @default.
• W2081906798 created "2016-06-24" @default.
• W2081906798 creator A5010777662 @default.
• W2081906798 creator A5015347620 @default.
• W2081906798 creator A5020779115 @default.
• W2081906798 creator A5037949399 @default.
• W2081906798 creator A5056077539 @default.
• W2081906798 creator A5085114730 @default.
• W2081906798 date "2008-03-04" @default.
• W2081906798 modified "2023-09-26" @default.
• W2081906798 title "Mitochondrial deafness alleles confer misreading of the genetic code" @default.
• W2081906798 cites W1574242652 @default.
• W2081906798 cites W1940308554 @default.
• W2081906798 cites W1967538502 @default.
• W2081906798 cites W1970052480 @default.
• W2081906798 cites W1983410328 @default.
• W2081906798 cites W1999652589 @default.
• W2081906798 cites W2000354545 @default.
• W2081906798 cites W2008676983 @default.
• W2081906798 cites W2015155411 @default.
• W2081906798 cites W2021674095 @default.
• W2081906798 cites W2035363248 @default.
• W2081906798 cites W2043190075 @default.
• W2081906798 cites W2044553149 @default.
• W2081906798 cites W2047393985 @default.
• W2081906798 cites W2052738911 @default.
• W2081906798 cites W2053520514 @default.
• W2081906798 cites W2063229027 @default.
• W2081906798 cites W2069765215 @default.
• W2081906798 cites W2071949088 @default.
• W2081906798 cites W2092617311 @default.
• W2081906798 cites W2109322309 @default.
• W2081906798 cites W2109953267 @default.
• W2081906798 cites W2112286580 @default.
• W2081906798 cites W2113635620 @default.
• W2081906798 cites W2114946849 @default.
• W2081906798 cites W2117430673 @default.
• W2081906798 cites W2119966574 @default.
• W2081906798 cites W2121916436 @default.
• W2081906798 cites W2126780661 @default.
• W2081906798 cites W2145583354 @default.
• W2081906798 cites W2149702670 @default.
• W2081906798 cites W2156866014 @default.
• W2081906798 cites W2171496353 @default.
• W2081906798 cites W4211080783 @default.
• W2081906798 doi "https://doi.org/10.1073/pnas.0707265105" @default.
• W2081906798 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2265171" @default.
• W2081906798 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18308926" @default.
• W2081906798 hasPublicationYear "2008" @default.
• W2081906798 type Work @default.
• W2081906798 sameAs 2081906798 @default.
• W2081906798 citedByCount "97" @default.
• W2081906798 countsByYear W20819067982012 @default.
• W2081906798 countsByYear W20819067982013 @default.
• W2081906798 countsByYear W20819067982014 @default.
• W2081906798 countsByYear W20819067982015 @default.
• W2081906798 countsByYear W20819067982016 @default.
• W2081906798 countsByYear W20819067982017 @default.
• W2081906798 countsByYear W20819067982018 @default.
• W2081906798 countsByYear W20819067982019 @default.
• W2081906798 countsByYear W20819067982020 @default.
• W2081906798 countsByYear W20819067982021 @default.
• W2081906798 countsByYear W20819067982022 @default.
• W2081906798 countsByYear W20819067982023 @default.
• W2081906798 crossrefType "journal-article" @default.
• W2081906798 hasAuthorship W2081906798A5010777662 @default.
• W2081906798 hasAuthorship W2081906798A5015347620 @default.
• W2081906798 hasAuthorship W2081906798A5020779115 @default.
• W2081906798 hasAuthorship W2081906798A5037949399 @default.
• W2081906798 hasAuthorship W2081906798A5056077539 @default.
• W2081906798 hasAuthorship W2081906798A5085114730 @default.
• W2081906798 hasBestOaLocation W20819067981 @default.
• W2081906798 hasConcept C104317684 @default.
• W2081906798 hasConcept C105580179 @default.
• W2081906798 hasConcept C10853874 @default.
• W2081906798 hasConcept C149364088 @default.
• W2081906798 hasConcept C180754005 @default.
• W2081906798 hasConcept C24586158 @default.
• W2081906798 hasConcept C2777787772 @default.
• W2081906798 hasConcept C2780090675 @default.
• W2081906798 hasConcept C501593827 @default.
• W2081906798 hasConcept C54355233 @default.
• W2081906798 hasConcept C67705224 @default.
• W2081906798 hasConcept C67905577 @default.
• W2081906798 hasConcept C86803240 @default.
• W2081906798 hasConcept C88478588 @default.
• W2081906798 hasConceptScore W2081906798C104317684 @default.
• W2081906798 hasConceptScore W2081906798C105580179 @default.
• W2081906798 hasConceptScore W2081906798C10853874 @default.
• W2081906798 hasConceptScore W2081906798C149364088 @default.
• W2081906798 hasConceptScore W2081906798C180754005 @default.
• W2081906798 hasConceptScore W2081906798C24586158 @default.
• W2081906798 hasConceptScore W2081906798C2777787772 @default.
• W2081906798 hasConceptScore W2081906798C2780090675 @default.
• W2081906798 hasConceptScore W2081906798C501593827 @default.
• W2081906798 hasConceptScore W2081906798C54355233 @default.
• W2081906798 hasConceptScore W2081906798C67705224 @default.
• W2081906798 hasConceptScore W2081906798C67905577 @default.

• next