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• W2081912897 abstract "The aim of this study was to characterize lansoprazole (LSP) /PVP solid dispersion prepared by a fluid-bed coating technique. In vitro dissolution test in pH 7.4 phosphate buffer indicated that the dissolution rate was dramatically enhanced even at an LSP/PVP ratio of 1/1.75 or with more PVP. DSC and powder X-ray diffractometry proved the absence of crystallinity in LSP/PVP solid dispersion at a ratio of 1/2 or with more PVP. However, at an LSP/PVP ratio of 1/1, the LSP melting and decomposition peaks could be observed by DSC indicating presence of LSP crystalline in LSP/PVP solid dispersion. The FTIR spectrometry indicated formation of hydrogen bond between LSP and PVP." @default.
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• W2081912897 date "2008-03-01" @default.
• W2081912897 modified "2023-10-16" @default.
• W2081912897 title "Physical characterization of lansoprazole/PVP solid dispersion prepared by fluid-bed coating technique" @default.
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• W2081912897 doi "https://doi.org/10.1016/j.powtec.2007.07.011" @default.
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