FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081924192> ?p ?o ?g. }

• W2081924192 endingPage "160" @default.
• W2081924192 startingPage "151" @default.
• W2081924192 abstract "Otsuka Long–Evans Tokushima Fatty (OLETF) rats are a new strain of spontaneous non-insulin-dependent diabetes mellitus (NIDDM) models. To evaluate the role of glucose transporters (GLUT) in the development of diabetes in this model, we examined the action of insulin on the translocation of GLUT4 and GLUT1 in isolated adipocytes, and the GLUT4 protein levels in muscles. Long–Evans Tokushima Otsuka (LETO) rats were used as a control strain. In adipocytes, the GLUT4 protein levels in OLETF rats at 30 weeks of age (diabetic stage) were considerably lower than those in LETO rats at the same age. At a pre-diabetic stage (7 weeks), there were no significant differences in GLUT4 protein levels in adipocytes between LETO and OLETF rats. However, the degree of GLUT4 translocation in OLETF rats was lower than that in LETO rats at 7 weeks of age. There were no differences in GLUT1 levels in adipocytes between the two strains. In muscles, the decrease in GLUT4 protein was observed in OLETF rats at 30 weeks of age. Whether such a difference is under the influence of hyperglycemia was also examined using rats rendered diabetic by 70% pancreatectomy. OLETF rats aged 7 weeks were subjected to partial pancreatectomy (Px) and sham pancreatectomy (sham). At 4 weeks after surgery, GLUT4 protein levels in adipose tissues and skeletal muscles were determined. GLUT4 decrease was observed for both tissues of hyperglycemic Px rats compared with euglycemic sham. Moreover, we examined the direct effect of glucose on GLUT4 protein using primary cultured adipocytes of OLETF rats at 5 weeks of age. After 7-day culture with normal (5.6 mmol/l) or high (25 mmol/l) concentrations of glucose, the GLUT4 protein levels in adipocytes decreased at 25 mmol/l glucose compared with 5.6 mmol/l glucose. These findings suggest an early defect in the insulin resistance of OLETF rats probably reflects impaired GLUT4 translocation. The GLUT4 decrease, which occurs later in the process appears to be a consequence, rather than a cause of diabetes in OLETF rats." @default.
• W2081924192 created "2016-06-24" @default.
• W2081924192 creator A5004646123 @default.
• W2081924192 creator A5028745838 @default.
• W2081924192 creator A5040778303 @default.
• W2081924192 creator A5060492381 @default.
• W2081924192 creator A5083865046 @default.
• W2081924192 creator A5085520010 @default.
• W2081924192 creator A5089026261 @default.
• W2081924192 creator A5090858958 @default.
• W2081924192 date "1997-12-01" @default.
• W2081924192 modified "2023-09-27" @default.
• W2081924192 title "Glucose transporter levels in a male spontaneous non-insulin-dependent diabetes mellitus rat of the Otsuka Long–Evans Tokushima Fatty strain" @default.
• W2081924192 cites W1506981847 @default.
• W2081924192 cites W1775749144 @default.
• W2081924192 cites W1965482152 @default.
• W2081924192 cites W1971060217 @default.
• W2081924192 cites W1986039769 @default.
• W2081924192 cites W1995939711 @default.
• W2081924192 cites W1996845220 @default.
• W2081924192 cites W2000859454 @default.
• W2081924192 cites W2007381693 @default.
• W2081924192 cites W2017752093 @default.
• W2081924192 cites W2018364757 @default.
• W2081924192 cites W2023144704 @default.
• W2081924192 cites W2028627182 @default.
• W2081924192 cites W2048870206 @default.
• W2081924192 cites W2049369403 @default.
• W2081924192 cites W2060616628 @default.
• W2081924192 cites W2087015690 @default.
• W2081924192 cites W2100837269 @default.
• W2081924192 cites W2143873575 @default.
• W2081924192 cites W2149665324 @default.
• W2081924192 cites W4231858802 @default.
• W2081924192 cites W4234778383 @default.
• W2081924192 cites W4243143392 @default.
• W2081924192 cites W4248842722 @default.
• W2081924192 cites W4251494161 @default.
• W2081924192 cites W4251893798 @default.
• W2081924192 cites W4254395696 @default.
• W2081924192 cites W4255327919 @default.
• W2081924192 doi "https://doi.org/10.1016/s0168-8227(97)00101-0" @default.
• W2081924192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9483380" @default.
• W2081924192 hasPublicationYear "1997" @default.
• W2081924192 type Work @default.
• W2081924192 sameAs 2081924192 @default.
• W2081924192 citedByCount "13" @default.
• W2081924192 countsByYear W20819241922012 @default.
• W2081924192 crossrefType "journal-article" @default.
• W2081924192 hasAuthorship W2081924192A5004646123 @default.
• W2081924192 hasAuthorship W2081924192A5028745838 @default.
• W2081924192 hasAuthorship W2081924192A5040778303 @default.
• W2081924192 hasAuthorship W2081924192A5060492381 @default.
• W2081924192 hasAuthorship W2081924192A5083865046 @default.
• W2081924192 hasAuthorship W2081924192A5085520010 @default.
• W2081924192 hasAuthorship W2081924192A5089026261 @default.
• W2081924192 hasAuthorship W2081924192A5090858958 @default.
• W2081924192 hasConcept C126322002 @default.
• W2081924192 hasConcept C134018914 @default.
• W2081924192 hasConcept C161573976 @default.
• W2081924192 hasConcept C171089720 @default.
• W2081924192 hasConcept C2776188179 @default.
• W2081924192 hasConcept C2777391703 @default.
• W2081924192 hasConcept C2777952866 @default.
• W2081924192 hasConcept C2779306644 @default.
• W2081924192 hasConcept C555293320 @default.
• W2081924192 hasConcept C71924100 @default.
• W2081924192 hasConceptScore W2081924192C126322002 @default.
• W2081924192 hasConceptScore W2081924192C134018914 @default.
• W2081924192 hasConceptScore W2081924192C161573976 @default.
• W2081924192 hasConceptScore W2081924192C171089720 @default.
• W2081924192 hasConceptScore W2081924192C2776188179 @default.
• W2081924192 hasConceptScore W2081924192C2777391703 @default.
• W2081924192 hasConceptScore W2081924192C2777952866 @default.
• W2081924192 hasConceptScore W2081924192C2779306644 @default.
• W2081924192 hasConceptScore W2081924192C555293320 @default.
• W2081924192 hasConceptScore W2081924192C71924100 @default.
• W2081924192 hasIssue "3" @default.
• W2081924192 hasLocation W20819241921 @default.
• W2081924192 hasLocation W20819241922 @default.
• W2081924192 hasOpenAccess W2081924192 @default.
• W2081924192 hasPrimaryLocation W20819241921 @default.
• W2081924192 hasRelatedWork W2069349303 @default.
• W2081924192 hasRelatedWork W2071007699 @default.
• W2081924192 hasRelatedWork W2077392184 @default.
• W2081924192 hasRelatedWork W2087127797 @default.
• W2081924192 hasRelatedWork W2102654574 @default.
• W2081924192 hasRelatedWork W2107503521 @default.
• W2081924192 hasRelatedWork W2998970372 @default.
• W2081924192 hasRelatedWork W3032853368 @default.
• W2081924192 hasRelatedWork W3113810870 @default.
• W2081924192 hasRelatedWork W4232601999 @default.
• W2081924192 hasVolume "38" @default.
• W2081924192 isParatext "false" @default.
• W2081924192 isRetracted "false" @default.
• W2081924192 magId "2081924192" @default.
• W2081924192 workType "article" @default.