Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081928641> ?p ?o ?g. }
- W2081928641 endingPage "e92461" @default.
- W2081928641 startingPage "e92461" @default.
- W2081928641 abstract "Biophysical properties of the tear film lipid layer are studied at the molecular level employing coarse grain molecular dynamics (MD) simulations with a realistic model of the human tear film. In this model, polar lipids are chosen to reflect the current knowledge on the lipidome of the tear film whereas typical Meibomian-origin lipids are included in the thick non-polar lipids subphase. Simulation conditions mimic those experienced by the real human tear film during blinks. Namely, thermodynamic equilibrium simulations at different lateral compressions are performed to model varying surface pressure, and the dynamics of the system during a blink is studied by non-equilibrium MD simulations. Polar lipids separate their non-polar counterparts from water by forming a monomolecular layer whereas the non-polar molecules establish a thick outermost lipid layer. Under lateral compression, the polar layer undulates and a sorting of polar lipids occurs. Moreover, formation of three-dimensional aggregates of polar lipids in both non-polar and water subphases is observed. We suggest that these three-dimensional structures are abundant under dynamic conditions caused by the action of eye lids and that they act as reservoirs of polar lipids, thus increasing stability of the tear film." @default.
- W2081928641 created "2016-06-24" @default.
- W2081928641 creator A5053470224 @default.
- W2081928641 creator A5066258109 @default.
- W2081928641 creator A5082095572 @default.
- W2081928641 date "2014-03-20" @default.
- W2081928641 modified "2023-10-17" @default.
- W2081928641 title "Organization of Lipids in the Tear Film: A Molecular-Level View" @default.
- W2081928641 cites W1597974772 @default.
- W2081928641 cites W1964805394 @default.
- W2081928641 cites W1966078827 @default.
- W2081928641 cites W1975365939 @default.
- W2081928641 cites W1977969200 @default.
- W2081928641 cites W1985179468 @default.
- W2081928641 cites W1986183780 @default.
- W2081928641 cites W1996135702 @default.
- W2081928641 cites W1999940631 @default.
- W2081928641 cites W2001333381 @default.
- W2081928641 cites W2001698037 @default.
- W2081928641 cites W2002376466 @default.
- W2081928641 cites W2003469863 @default.
- W2081928641 cites W2005178146 @default.
- W2081928641 cites W2005288369 @default.
- W2081928641 cites W2010954738 @default.
- W2081928641 cites W2014111132 @default.
- W2081928641 cites W2015157949 @default.
- W2081928641 cites W2019068845 @default.
- W2081928641 cites W2021330026 @default.
- W2081928641 cites W2024119736 @default.
- W2081928641 cites W2028465131 @default.
- W2081928641 cites W2029443055 @default.
- W2081928641 cites W2029606389 @default.
- W2081928641 cites W2032032786 @default.
- W2081928641 cites W2034214429 @default.
- W2081928641 cites W2035266068 @default.
- W2081928641 cites W2035297037 @default.
- W2081928641 cites W2041843614 @default.
- W2081928641 cites W2049286183 @default.
- W2081928641 cites W2052130892 @default.
- W2081928641 cites W2052607038 @default.
- W2081928641 cites W205551345 @default.
- W2081928641 cites W2066259235 @default.
- W2081928641 cites W2073890475 @default.
- W2081928641 cites W2076933231 @default.
- W2081928641 cites W2078263456 @default.
- W2081928641 cites W2081671530 @default.
- W2081928641 cites W2081693079 @default.
- W2081928641 cites W2081724315 @default.
- W2081928641 cites W2084093170 @default.
- W2081928641 cites W2086186627 @default.
- W2081928641 cites W2092694413 @default.
- W2081928641 cites W2093520791 @default.
- W2081928641 cites W2093635706 @default.
- W2081928641 cites W2104720940 @default.
- W2081928641 cites W2119267663 @default.
- W2081928641 cites W2127236863 @default.
- W2081928641 cites W2130394450 @default.
- W2081928641 cites W2147916356 @default.
- W2081928641 cites W2163221541 @default.
- W2081928641 cites W2205553920 @default.
- W2081928641 cites W2318598399 @default.
- W2081928641 cites W2323788459 @default.
- W2081928641 cites W2335626745 @default.
- W2081928641 cites W2474310 @default.
- W2081928641 cites W2598546209 @default.
- W2081928641 cites W4236274645 @default.
- W2081928641 cites W4362204629 @default.
- W2081928641 cites W2013095373 @default.
- W2081928641 doi "https://doi.org/10.1371/journal.pone.0092461" @default.
- W2081928641 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3961367" @default.
- W2081928641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24651175" @default.
- W2081928641 hasPublicationYear "2014" @default.
- W2081928641 type Work @default.
- W2081928641 sameAs 2081928641 @default.
- W2081928641 citedByCount "46" @default.
- W2081928641 countsByYear W20819286412014 @default.
- W2081928641 countsByYear W20819286412015 @default.
- W2081928641 countsByYear W20819286412016 @default.
- W2081928641 countsByYear W20819286412017 @default.
- W2081928641 countsByYear W20819286412018 @default.
- W2081928641 countsByYear W20819286412019 @default.
- W2081928641 countsByYear W20819286412020 @default.
- W2081928641 countsByYear W20819286412021 @default.
- W2081928641 countsByYear W20819286412022 @default.
- W2081928641 countsByYear W20819286412023 @default.
- W2081928641 crossrefType "journal-article" @default.
- W2081928641 hasAuthorship W2081928641A5053470224 @default.
- W2081928641 hasAuthorship W2081928641A5066258109 @default.
- W2081928641 hasAuthorship W2081928641A5082095572 @default.
- W2081928641 hasBestOaLocation W20819286411 @default.
- W2081928641 hasConcept C121332964 @default.
- W2081928641 hasConcept C12554922 @default.
- W2081928641 hasConcept C127413603 @default.
- W2081928641 hasConcept C1276947 @default.
- W2081928641 hasConcept C147597530 @default.
- W2081928641 hasConcept C159467904 @default.
- W2081928641 hasConcept C171250308 @default.
- W2081928641 hasConcept C178790620 @default.