Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081935982> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2081935982 endingPage "566" @default.
- W2081935982 startingPage "563" @default.
- W2081935982 abstract "Matrix metalloproteinases (MMPs) are known to be activated in the brain by epileptic seizures and elevated MMP-9 activity has been found in a genetic model of generalized absence epilepsy (Wistar Albino Glaxo Rijswijk/WAG/Rij rats). In this study we posed the question, whether MMP inhibitory dose of doxycycline (20 mg/kg) could affect the spike-wave-discharges (SWDs) of the WAG/Rij rat. We found that intraperitoneal (i.p.) administration of 20 mg/kg doxycycline significantly increased the incidence and duration of SWDs for 4 h. As doxycycline has both MMP inhibitory and anti-inflammatory effects we also tested a lower dose of doxycycline (10 mg/kg, i.p.) and a selective broad-spectrum MMP inhibitor GM6001 (N-[2(R)-2-(hydroxamido carbonylmethyl)-4-methylpentanoyl]-l-tryptophane methylamide) intracerebroventricularly (i.c.v., 10 ng/rat). While 10 mg/kg doxycycline significantly increased the SWD number for 1 h, GM6001 significantly increased the SWD number during the whole 4-h recording period. Our results could indicate that the induction of MMPs in the epileptic brain, besides contributing to structural remodeling, would also be associated with such functions as homeostatic synaptic plasticity which might counteract epileptic seizures." @default.
- W2081935982 created "2016-06-24" @default.
- W2081935982 creator A5003255265 @default.
- W2081935982 creator A5014897019 @default.
- W2081935982 creator A5060217047 @default.
- W2081935982 creator A5060822510 @default.
- W2081935982 creator A5077240772 @default.
- W2081935982 date "2011-10-01" @default.
- W2081935982 modified "2023-10-18" @default.
- W2081935982 title "Doxycycline could aggravate the absence-like epileptic seizures of WAG/Rij rats via matrix metalloproteinase inhibition" @default.
- W2081935982 cites W1543643556 @default.
- W2081935982 cites W1558419262 @default.
- W2081935982 cites W1963545516 @default.
- W2081935982 cites W1964178903 @default.
- W2081935982 cites W1965627514 @default.
- W2081935982 cites W1972906571 @default.
- W2081935982 cites W1998608791 @default.
- W2081935982 cites W1999412359 @default.
- W2081935982 cites W2010206045 @default.
- W2081935982 cites W2047535883 @default.
- W2081935982 cites W2051507702 @default.
- W2081935982 cites W2071863466 @default.
- W2081935982 cites W2102444756 @default.
- W2081935982 cites W2124054487 @default.
- W2081935982 cites W2129208893 @default.
- W2081935982 doi "https://doi.org/10.1016/j.neuint.2011.06.016" @default.
- W2081935982 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21740942" @default.
- W2081935982 hasPublicationYear "2011" @default.
- W2081935982 type Work @default.
- W2081935982 sameAs 2081935982 @default.
- W2081935982 citedByCount "7" @default.
- W2081935982 countsByYear W20819359822012 @default.
- W2081935982 countsByYear W20819359822013 @default.
- W2081935982 countsByYear W20819359822014 @default.
- W2081935982 countsByYear W20819359822016 @default.
- W2081935982 countsByYear W20819359822018 @default.
- W2081935982 countsByYear W20819359822019 @default.
- W2081935982 crossrefType "journal-article" @default.
- W2081935982 hasAuthorship W2081935982A5003255265 @default.
- W2081935982 hasAuthorship W2081935982A5014897019 @default.
- W2081935982 hasAuthorship W2081935982A5060217047 @default.
- W2081935982 hasAuthorship W2081935982A5060822510 @default.
- W2081935982 hasAuthorship W2081935982A5077240772 @default.
- W2081935982 hasConcept C109523444 @default.
- W2081935982 hasConcept C126322002 @default.
- W2081935982 hasConcept C134018914 @default.
- W2081935982 hasConcept C169760540 @default.
- W2081935982 hasConcept C17077164 @default.
- W2081935982 hasConcept C185592680 @default.
- W2081935982 hasConcept C2777179404 @default.
- W2081935982 hasConcept C2778186239 @default.
- W2081935982 hasConcept C501593827 @default.
- W2081935982 hasConcept C55493867 @default.
- W2081935982 hasConcept C71924100 @default.
- W2081935982 hasConcept C86803240 @default.
- W2081935982 hasConcept C98274493 @default.
- W2081935982 hasConceptScore W2081935982C109523444 @default.
- W2081935982 hasConceptScore W2081935982C126322002 @default.
- W2081935982 hasConceptScore W2081935982C134018914 @default.
- W2081935982 hasConceptScore W2081935982C169760540 @default.
- W2081935982 hasConceptScore W2081935982C17077164 @default.
- W2081935982 hasConceptScore W2081935982C185592680 @default.
- W2081935982 hasConceptScore W2081935982C2777179404 @default.
- W2081935982 hasConceptScore W2081935982C2778186239 @default.
- W2081935982 hasConceptScore W2081935982C501593827 @default.
- W2081935982 hasConceptScore W2081935982C55493867 @default.
- W2081935982 hasConceptScore W2081935982C71924100 @default.
- W2081935982 hasConceptScore W2081935982C86803240 @default.
- W2081935982 hasConceptScore W2081935982C98274493 @default.
- W2081935982 hasIssue "5" @default.
- W2081935982 hasLocation W20819359821 @default.
- W2081935982 hasLocation W20819359822 @default.
- W2081935982 hasOpenAccess W2081935982 @default.
- W2081935982 hasPrimaryLocation W20819359821 @default.
- W2081935982 hasRelatedWork W1966504330 @default.
- W2081935982 hasRelatedWork W1966775726 @default.
- W2081935982 hasRelatedWork W1979139803 @default.
- W2081935982 hasRelatedWork W2030889776 @default.
- W2081935982 hasRelatedWork W2037631372 @default.
- W2081935982 hasRelatedWork W2040058909 @default.
- W2081935982 hasRelatedWork W2132898409 @default.
- W2081935982 hasRelatedWork W2748952813 @default.
- W2081935982 hasRelatedWork W2899084033 @default.
- W2081935982 hasRelatedWork W4249176446 @default.
- W2081935982 hasVolume "59" @default.
- W2081935982 isParatext "false" @default.
- W2081935982 isRetracted "false" @default.
- W2081935982 magId "2081935982" @default.
- W2081935982 workType "article" @default.