FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2081938410> ?p ?o ?g. }

• W2081938410 endingPage "258" @default.
• W2081938410 startingPage "250" @default.
• W2081938410 abstract "<i>Background/Aims:</i> GBR12909 has been reported to possess anticonvulsant activity with focal brain perfusion to the hippocampus of pilocarpine, although an earlier publication suggested any anticonvulsant effects were only mild. Here we further explored the anticonvulsant potential of GBR12909 with a suite of anticonvulsant assays in both zebrafish and mammals and then explored whether it possessed any QT effects which might limit clinical utility. <i>Methods:</i> We assessed the anticonvulsant effects of GBR12909 in zebrafish pentylenetetrazole (PTZ), mammalian maximal electroshock and PTZ models of generalized epilepsy and a rodent hippocampal kindling model. Cardiac effects were assessed in zebrafish and man. <i>Results:</i> GBR12909 possesses anticonvulsant activity in zebrafish and rodent models of generalized epilepsy. However, phase 1 human data indicated potential QT effects. Subsequent testing in a zebrafish QT assay confirmed marked arrhythmogenic potential. <i>Conclusion:</i> Further clinical development of GBR12909 in epilepsy was considered inappropriate because of insufficient window between the therapeutic effects and the cardiac arrhythmia problems identified in zebrafish assays. Any further development based on this mechanism of action should avoid the GBR12909 chemical scaffold, or involve structure-activity dissociation of its neurological and cardiac effects." @default.
• W2081938410 created "2016-06-24" @default.
• W2081938410 creator A5007520181 @default.
• W2081938410 creator A5008732721 @default.
• W2081938410 creator A5017073522 @default.
• W2081938410 creator A5017425394 @default.
• W2081938410 creator A5023145787 @default.
• W2081938410 creator A5023462554 @default.
• W2081938410 creator A5027332996 @default.
• W2081938410 creator A5031331094 @default.
• W2081938410 creator A5065402843 @default.
• W2081938410 creator A5079782913 @default.
• W2081938410 date "2007-01-01" @default.
• W2081938410 modified "2023-10-06" @default.
• W2081938410 title "GBR12909 Possesses Anticonvulsant Activity in Zebrafish and Rodent Models of Generalized Epilepsy but Cardiac Ion Channel Effects Limit Its Clinical Utility" @default.
• W2081938410 cites W1967695541 @default.
• W2081938410 cites W1975343918 @default.
• W2081938410 cites W1978351743 @default.
• W2081938410 cites W1994683039 @default.
• W2081938410 cites W1995551635 @default.
• W2081938410 cites W2003161933 @default.
• W2081938410 cites W2009766076 @default.
• W2081938410 cites W2048782739 @default.
• W2081938410 cites W2057447444 @default.
• W2081938410 cites W2058207889 @default.
• W2081938410 cites W2058895283 @default.
• W2081938410 cites W2072320653 @default.
• W2081938410 cites W2074055668 @default.
• W2081938410 cites W2099899109 @default.
• W2081938410 cites W2103946141 @default.
• W2081938410 cites W2149498611 @default.
• W2081938410 cites W2149657563 @default.
• W2081938410 doi "https://doi.org/10.1159/000102061" @default.
• W2081938410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17476122" @default.
• W2081938410 hasPublicationYear "2007" @default.
• W2081938410 type Work @default.
• W2081938410 sameAs 2081938410 @default.
• W2081938410 citedByCount "14" @default.
• W2081938410 countsByYear W20819384102012 @default.
• W2081938410 countsByYear W20819384102014 @default.
• W2081938410 countsByYear W20819384102021 @default.
• W2081938410 countsByYear W20819384102022 @default.
• W2081938410 countsByYear W20819384102023 @default.
• W2081938410 crossrefType "journal-article" @default.
• W2081938410 hasAuthorship W2081938410A5007520181 @default.
• W2081938410 hasAuthorship W2081938410A5008732721 @default.
• W2081938410 hasAuthorship W2081938410A5017073522 @default.
• W2081938410 hasAuthorship W2081938410A5017425394 @default.
• W2081938410 hasAuthorship W2081938410A5023145787 @default.
• W2081938410 hasAuthorship W2081938410A5023462554 @default.
• W2081938410 hasAuthorship W2081938410A5027332996 @default.
• W2081938410 hasAuthorship W2081938410A5031331094 @default.
• W2081938410 hasAuthorship W2081938410A5065402843 @default.
• W2081938410 hasAuthorship W2081938410A5079782913 @default.
• W2081938410 hasConcept C104317684 @default.
• W2081938410 hasConcept C148762608 @default.
• W2081938410 hasConcept C15744967 @default.
• W2081938410 hasConcept C169760540 @default.
• W2081938410 hasConcept C185592680 @default.
• W2081938410 hasConcept C2775858608 @default.
• W2081938410 hasConcept C2776878037 @default.
• W2081938410 hasConcept C2778186239 @default.
• W2081938410 hasConcept C55493867 @default.
• W2081938410 hasConcept C71924100 @default.
• W2081938410 hasConcept C98274493 @default.
• W2081938410 hasConceptScore W2081938410C104317684 @default.
• W2081938410 hasConceptScore W2081938410C148762608 @default.
• W2081938410 hasConceptScore W2081938410C15744967 @default.
• W2081938410 hasConceptScore W2081938410C169760540 @default.
• W2081938410 hasConceptScore W2081938410C185592680 @default.
• W2081938410 hasConceptScore W2081938410C2775858608 @default.
• W2081938410 hasConceptScore W2081938410C2776878037 @default.
• W2081938410 hasConceptScore W2081938410C2778186239 @default.
• W2081938410 hasConceptScore W2081938410C55493867 @default.
• W2081938410 hasConceptScore W2081938410C71924100 @default.
• W2081938410 hasConceptScore W2081938410C98274493 @default.
• W2081938410 hasIssue "4" @default.
• W2081938410 hasLocation W20819384101 @default.
• W2081938410 hasLocation W20819384102 @default.
• W2081938410 hasOpenAccess W2081938410 @default.
• W2081938410 hasPrimaryLocation W20819384101 @default.
• W2081938410 hasRelatedWork W1578462026 @default.
• W2081938410 hasRelatedWork W2098439253 @default.
• W2081938410 hasRelatedWork W2101607104 @default.
• W2081938410 hasRelatedWork W2138730144 @default.
• W2081938410 hasRelatedWork W2402894627 @default.
• W2081938410 hasRelatedWork W2412133698 @default.
• W2081938410 hasRelatedWork W2642041685 @default.
• W2081938410 hasRelatedWork W3000739770 @default.
• W2081938410 hasRelatedWork W4206837486 @default.
• W2081938410 hasRelatedWork W4300594455 @default.
• W2081938410 hasVolume "79" @default.
• W2081938410 isParatext "false" @default.
• W2081938410 isRetracted "false" @default.
• W2081938410 magId "2081938410" @default.
• W2081938410 workType "article" @default.